Between 1990 and 1994, 89 cattle with signs of affection of the central nervous system were referred to the Clinic for Food Animals and Horses, University of Bern; in 17 cases of which, cerebral listeriosis was diagnosed. History, clinical, hematologic findings and cerebrospinal fluid analysis at admission were evaluated retrospectively. Four cattle were slaughtered after cerebral listeriosis had been diagnosed clinically because of economic reasons. Therapy, consisting of administration of penicillin (i.m./i.v.), intravenous fluids (including bicarbonate replacement), and oral fluids and rumen juice was initiated in the remaining 13 cases. Five of the 13 cattle were refractory to treatment and had to be euthanatized, one to two days after initiation of therapy. Clinical diagnosis of cerebral listeriosis was confirmed by histological examination of brain stem tissue in all nine cattle that were slaughtered or euthanatized; however, Listeria monocytogenes was isolated by standard culturing of brain stem tissue in two of these cases only. Eight to 62 months after discharge from the clinic, telephone interview with the owners of the surviving animals revealed that recovery had been uneventful and satisfactory in all of the eight cases.

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