Tests performed on 48 white rats were designed to evaluate the effect of such antioxidants as Allopurinol, Vitamin C, and Desferal on the lipid quantity in the rat heart muscle. The test animals were divided into control, Allopurinol, Vitamin C, and Desferal test groups in which free fatty acids, triglycerides, phospholipids, and total cholesterol were determined. It was observed that under the influence of Allopurinol and Vitamin C the heart muscle was bereaved of the essential energy compound, free fatty acids, to a large extent. This may be caused by the participation of these antioxidants in the redox reactions in organisms. The antioxidant applied in the experiments did not cause any changes in the contents of the other lipids under determination, i.e. triglycerides, phospholipids, and cholesterol. The maintenance of a constant level of these compounds is probably beneficial both for the heart and thus for the whole organism.
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Nutrients
November 2024
Department of Physical Education and Sport Science, University of Thessaly, Karies, 382 21 Trikala, Greece.
Soccer is linked to an acute inflammatory response and the release of reactive oxygen species (ROS). Antioxidant supplements have shown promising effects in reducing muscle damage and oxidative stress and enhancing the recovery process after eccentric exercise. This critical review highlights the influence of antioxidant supplements on performance and recovery following soccer-related activity, training, or competition.
View Article and Find Full Text PDFSleep Breath
August 2024
Department of Pulmonary, Critical Care, and Sleep Medicine, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, India, 110029.
Purpose: Obstructive sleep apnea (OSA) is a common clinical problem that is associated with adverse cardiovascular outcomes attributed to the oxidative stress due to sympathetic overstimulation. Treatment approaches targeting oxidative stress have been tried by multiple investigators. This systematic review and meta-analysis evaluated the efficacy and safety of such approaches.
View Article and Find Full Text PDFArch Med Sci
June 2023
Department of Oncology, Affiliated Hospital of Qinghai University, Xining, China.
Introduction: The aim of the study was to evaluate the preventive effect of 13 drugs on colorectal cancer (CRC) and guide the clinical application of these drugs.
Material And Methods: PubMed, Web of Science, Embase, Cochrane Library, and China National Knowledge Infrastructure were searched for randomized controlled trials (RCTs) and cohort studies. The Cochrane bias risk assessment tool and the Newcastle-Ottawa Scale quality evaluation tool were used to evaluate the quality of the included RCTs and cohort studies.
Neurol Sci
November 2023
Department of Neurology, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, 1090, Brussels, Belgium.
A right-handed woman in her 80s was admitted to the emergency department 1 h after sudden-onset global aphasia and right-sided hemiparesis. Medical history included arterial hypertension, dyslipidemia, hyperuricemia, aortic stenosis, osteoporosis, and recent pulmonary embolism. Medication consisted of apixaban, bisoprolol, hydrochlorothiazide, allopurinol, fenofibrate, and vitamin D.
View Article and Find Full Text PDFBiomed Res Int
July 2023
Asymmetric Therapeutics LLC, 141 Main St., P.O. Box J, Unadilla, NY 13849, USA.
Although the management options for psoriasis have progressed with the use of systemic agents, there are few efficacious nonsteroidal topical therapies for patients with limited or lower grade disease. The effects of allopurinol (Allo) and glutathione (GSH) were examined in two different models for psoriasis. In the first model, human immortalized keratinocytes (HaCaT) were treated with M5 cocktail (IL-17A, IL-22, oncostatin M, IL-1, and TNF-) in four interventional groups (control, Allo, oxypurinol (Oxy), and methotrexate (MTX)).
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