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Singular case report of familial hypocalciuric hypercalcemia: a rare diagnosis of hypercalcemia in the older people.
Aging Male
December 2025
Clinical Gerontology Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
Objective: to report a case of familial hypocalciuric hypercalcemia (FHH) in an older patient and highlight the diagnostic challenges in geriatric populations.
Case Presentation: We report the diagnosis of FHH in an 88-year-old polypathological patient with hypercalcemia discovered during a check-up for cardiac decompensation. Despite a confusing clinical presentation with gout symptoms, including repeated episodes of knee arthritis, persistent hypercalcemia conducted further investigations.
Article Synopsis
- Tumoral calcinosis (TC) is a rare disease that causes hard lumps of calcium to form in the body.
- It happens often in people with severe kidney problems.
- Doctors may need to do surgery to help with the symptoms if it gets too serious.
Calcium Pyrophosphate Crystal Deposition: Insights to Risks Factors and Associated Conditions.
Curr Rheumatol Rep
November 2024
University of Cyprus Medical School, Nicosia, Cyprus.
Article Synopsis
- The review focuses on CPPD (Calcium pyrophosphate deposition disease), outlining its medical conditions and risk factors, particularly in older adults.
- Recent studies highlight a connection between CPPD and systemic conditions, notably an increased risk of cardiovascular diseases along with associations to other metabolic and endocrine disorders.
- There is a need for further research to understand the mechanisms behind these associations and to create targeted therapies for better patient outcomes.
Calcium pyrophosphate deposition disease.
Lancet Rheumatol
November 2024
Academic Rheumatology, University of Nottingham, Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham, UK.
Article Synopsis
- - Calcium pyrophosphate deposition disease (CPPD) occurs when CPP crystals build up in joints, triggering inflammation and arthritis, particularly in older individuals over 60, and is linked to cartilage deterioration and osteoarthritis.
- - Common risk factors for CPPD include aging, past joint injuries, and certain metabolic conditions or genetic factors. Diagnosis relies on detecting CPP crystals in joint fluid and imaging techniques like X-rays and ultrasound.
- - Current treatment focuses on managing inflammation since there’s no cure for dissolving CPP crystals; options include prednisone for acute arthritis, low-dose colchicine, and potential use of biologics for stubborn cases.
Multisystem Imaging Manifestations of Kidney Failure.
Radiographics
August 2024
From the Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 559905 (P.S.R., G.S.); UT Southwestern Medical Center, Dallas, Tex (K.V.); University of Washington, Seattle, Wash (N.V., B.M., M.C.); and Mayo Clinic, Jacksonville, Fla (A.K.A.).
Kidney failure (KF) refers to a progressive decline in glomerular filtration rate to below 15 ml/min per 1.73 m, necessitating renal replacement therapy with dialysis or renal transplant. The hemodynamic and metabolic alterations in KF combined with a proinflammatory and coagulopathic state leads to complex multisystemic complications.
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