A retrospective analysis of the files of 25 patients with an early glottic well-differentiated untreated invasive squamous cell carcinoma, staged as T1-T2-NO with a complete response after cisplatin-fluorouracil neo-adjuvant chemotherapy, managed with exclusive chemotherapy is presented. Five-year actuarial (Kaplan-Meier method) survival and local control estimate was 83.8% and 33.6%, respectively. Patients with local recurrence after exclusive chemotherapy were always salvaged with partial laryngeal surgery or radiation therapy resulting in an overall 100% local control and laryngeal preservation rate. Five-year actuarial nodal recurrence distant metastasis, and metachronous second primary estimate was 0%, 0% and 20.2%, respectively.
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