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Role of the Lymphocyte Profile in Mediastinal Lymph Nodes in the Differential Diagnosis of Sarcoidosis and Tuberculous Lymphadenitis Patients Undergoing EBUS-TBNA.

Diagn Cytopathol

February 2025

Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Article Synopsis
  • The study investigates the use of lymphocyte profiling in diagnosing sarcoidosis compared to tuberculous lymphadenitis, addressing gaps in previous research.
  • Researchers analyzed lymph node fluid from patients using flow cytometry during a procedure called EBUS-TBNA, finding notable differences in lymphocyte composition between sarcoidosis and TBLA patients.
  • The study concludes that lymphocyte profiling can enhance diagnostic accuracy for sarcoidosis, particularly using the CD4/CD8 ratio and a combination of lymphocyte parameters.
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Epidemiological assessment of non-tuberculous mycobacterial cervicofacial lymphadenitis: A PHIS database study.

Int J Pediatr Otorhinolaryngol

July 2024

Case Western Reserve University School of Medicine, Cleveland, OH, USA; Division of Pediatric Otolaryngology, University Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH, USA. Electronic address:

Objective: Cervicofacial lymphadenitis caused by non-tubercular mycobacterial (NTM) infections has the highest infection rate in children. Our objective was to assess patient demographics, treatment methods, and the impact of weather and geography on the incidence of disease in patients with NTM cervicofacial lymphadenitis.

Methods: The Pediatric Health Information System (PHIS) database was queried for data on all patients diagnosed with concurrent cervicofacial lymphadenopathy and NTM infection from 2004 to 2022.

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Pitfalls in Lymph Node Fine Needle Aspiration Cytology.

Acta Cytol

August 2024

Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Background: Fine needle aspiration cytology (FNAC) is an accurate, minimally invasive, and cost-effective biopsy method for enlarged lymph nodes. While the role of lymph node FNAC in the diagnosis of infectious or reactive conditions and metastatic malignancy is unquestioned, differing views still exist on its role in the diagnosis of lymphoma. Nevertheless, regardless of the practice setting, pitfalls and potential for error exist, and it is incumbent upon the pathologist to be aware of these pitfalls, as this is the first line of defence against errors.

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Background: The gene codes the MDA5 protein and the gene codes the RIG-I receptor. Both proteins are parts of the interferon (IFN) I signaling pathway and are responsible for antiviral defense and innate immune response. IFIH1 and DDX58 polymorphisms are associated with a spectrum of autoimmune diseases.

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A female, 1.5 years old, mixed‑breed dog, was presented for left hind limb lameness. Radiographs revealed an irregular periosteal proliferation on the left iliac wing.

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