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- Carcinosarcoma is a rare and aggressive malignant tumor of the uterus and ovaries, often confused with high-grade endometrial carcinoma due to similar symptoms.
- A study conducted between August 2021 and July 2024 analyzed six cases, confirming their diagnosis through a panel of immunohistochemical markers, with mean patient age being 51.5 years.
- Histologically, the tumors displayed a biphasic composition of carcinomatous and sarcomatous elements, with notable positivity for markers like cytokeratin and vimentin, highlighting their complex nature and aggressive behavior in elderly females.
Trends in Clinico-radiological and Laboratory Characteristics of All-Cause Meningoencephalitis in Western Rajasthan.
Ann Indian Acad Neurol
November 2024
Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Article Synopsis
- The study focuses on meningoencephalitis, which involves both meningitis and encephalitis, aiming to analyze the clinical features, lab tests, imaging results, and factors predicting outcomes in affected patients.
- Conducted from July 2021 to March 2023, it enrolled patients who met the case definitions for meningitis and encephalitis, tracking their mortality and health recovery over one and three months post-discharge.
- Out of 102 cases, various infectious and non-infectious causes were identified, with notable findings in cerebrospinal fluid analysis and imaging; particularly, high mortality rates were seen in fungal and rickettsial cases while patient recovery varied depending on the type of meningoencephalitis experienced
A Case Report on Carcinomatous Meningitis in a Patient With Double-Hit Lymphoma.
Cureus
September 2024
Hematology and Oncology, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York, USA.
A double-hit lymphoma is a high-grade B-cell lymphoma (HGBCL) with and rearrangements. It is characterized by a rapidly progressive advanced disease, high rates of central nervous involvement (CNS), refractoriness to conventional chemotherapy, and poorer clinical outcomes. Carcinomatous meningitis is a condition in which cancer cells metastasize to the meninges without involving the brain parenchyma; this phenomenon has also been reported in the literature by other terms like "leptomeningeal meningitis," "leptomeningeal carcinomatosis," "leptomeningeal metastasis," or "neoplastic meningitis.
View Article and Find Full Text PDFSpotlight on Carcinosarcoma of the Ovary: A Scoping Review.
Acta Medica (Hradec Kralove)
September 2024
Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Malta.
Ovarian carcinosarcoma, also referred as malignant mixed Mullerian tumour, is an uncommon, highly aggressive and malignant neoplasm which makes up 1 to 4% of all ovarian tumours. It is biphasic involving both malignant sarcomatous (mesenchymal) and carcinomatous (epithelial) cells. There are various subtypes such as serous and endometrioid.
View Article and Find Full Text PDFLeft homonymous hemianopia as an atypical manifestation of isolated pachymeningeal metastasis secondary to breast cancer: Case report and review of the literature.
Radiol Case Rep
November 2024
Department of Neurology and Neurophysiology, Mohammed V Military Teaching Hospital, University of King Mohammed V-Souissi, Rabat, Morocco.
Breast cancer is the most frequently diagnosed cancer in women and is caused by the uncontrolled proliferation of breast cells. Metastases from breast cancer to the central nervous system have been described frequently in the literature, but dural metastases without cerebral parenchymal involvement are rarely reported. The latter condition is known as isolated pachymeningeal metastasis (IPM).
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