The fractional composition of the vaccine preparation obtained by the hydroxylamine treatment of K. pneumoniae 204 cells was studied with the use of gel chromatography in sepharose CL-6B. The preparation was shown to form 2 peaks, only the first high molecular peak being serologically active. The method for the treatment of the culture, obtained directly from a fermenter and stored in a frozen state before treatment, was proposed. In the technology of the manufacture of Klebsiella vaccine preparation the possibility of replacing dialysis with gel chromatography was shown.

Download full-text PDF

Source

Publication Analysis

Top Keywords

fractional composition
8
vaccine preparation
8
gel chromatography
8
[the fractional
4
composition hydroxylamine
4
hydroxylamine preparations
4
preparations lipopolysaccharide
4
lipopolysaccharide vaccinal
4
vaccinal strain
4
strain klebsiella
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!