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Systemic Lupus Erythematosus (SLE) Induced by ASIA Syndrome After the Aesthetic Medicine Procedures-A Case Report.
J Clin Med
December 2024
Department of Rheumatology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is a rare condition caused by an immune response associated with over-reactivity of the immune system, triggered by adjuvants. The most common adjuvants are aluminium salts but can also be bioimplants or infectious agents. It may lead to the development of various autoimmunologic diseases.
View Article and Find Full Text PDFPsychiatric Symptoms in Wilson's Disease-Consequence of Gene Mutations or Just Coincidence?-Possible Causal Cascades and Molecular Pathways.
Int J Mol Sci
November 2024
Second Department of Neurology, Institute of Psychiatry and Neurology, Sobieskiego Street 9, 02-957 Warsaw, Poland.
Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism. The genetic defect in WD affects the gene, which encodes the ATP7B transmembrane protein, which is essential for maintaining normal copper homeostasis in the body. It is primarily expressed in the liver and acts by incorporating copper into ceruloplasmin (Cp), the major copper transport protein in the blood.
View Article and Find Full Text PDFAutoimmune inflammatory reactions triggered by the COVID-19 genetic vaccines in terminally differentiated tissues.
Autoimmunity
December 2023
Cardiology, Truth for Health Foundation, Tucson, AZ, USA.
Article Synopsis
- The global pandemic of COVID-19 led to widespread vaccination even among low-risk groups, raising safety concerns.
- Research indicates that COVID-19 genetic vaccines can distribute throughout the body, including sensitive areas like the heart and brain, potentially triggering harmful immune responses.
- The article emphasizes the need for detailed studies on how these vaccines distribute in the body and the importance of evaluating their risks and benefits based on age.
[Side effects of immune checkpoint inhibitor therapy : What intensive care specialists need to know].
Med Klin Intensivmed Notfmed
March 2024
Intensivstation 13i2, Universitätsklinik für Innere Medizin I, Medizinische Universität Wien, Wien, Österreich.
Immunotherapies, and in particular checkpoint inhibitors, have revolutionized the treatment of cancer. However, due to their mechanism of action, the activation of the body's own T cells, side effects are frequently associated with these therapies. So-called immune-related adverse events (irAEs) manifest as autoimmunological phenomena, can occur in any organ system, and even lead to severe organ failure.
View Article and Find Full Text PDFParavertebral fibrous pseudotumor: Four cases of a distinctive tumefactive lesion overlapping with eosinophilic angiocentric fibrosis and tumoral erythema elevatum diutinum.
Ann Diagn Pathol
February 2023
Institute of Pathology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Germany; Institut für Pathologie, Klinikum Bayreuth GmbH, Bayreuth, Germany.
Eosinophilic angiocentric fibrosis (EAF) is a rare tumefactive fibroinflammatory disease with predilection for the upper respiratory tract, characterized by concentric (onionskin) fibrosis around small arterioles with variable intervening storiform fibrosis admixed with chronic inflammatory infiltrates rich in eosinophils. Erythema elevatum diutinum (EED), another autoimmunological disorder that mainly affects acral sites and extensor surfaces, is characterized by neutrophilic leukocytoclastic vasculitis. Rarely, older EED lesions may present as tumefactive nodular (pseudotumoral) fibrous masses closely mimicking EAF.
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