AI Article Synopsis
- Limited information was available on how effective an inactivated hepatitis A vaccine was when given as part of a larger vaccination schedule.
- Dutch marines received the vaccine along with various others before a deployment to Cambodia, and their hepatitis A antibody levels were tested before and after a booster shot.
- At 8 months, only 52% and 81% of the marines had developed antibodies according to two different tests, with older age and prior typhoid vaccination being linked to lower rates of seroconversion; however, by 11 months, almost all had shown antibody presence.
Article Abstract
Limited information existed on the immunogenicity of an inactivated hepatitis A vaccine as part of an extensive vaccination schedule. Dutch marines bound for duty in Cambodia received inactivated hepatitis A vaccine (720 ELISA units of antigen, two intra-gluteal doses at a 2-week interval before departure and an intra-deltoid booster vaccination after 8 months) simultaneously with several other vaccines. Hepatitis A antibodies were determined in blood-samples drawn before and after the booster vaccination, using two laboratory tests (modified HAVAB and SBB-ELISA). At 8 months, before the booster vaccination, 52% (modified HAVAB) and 81% (SBB-ELISA) had seroconverted. Risk factors for non-seroconversion were increasing age and a typhoid vaccination. At 11 months 97.6% (modified HAVAB) and 100% (SBB-ELISA) had seroconverted. Non-seroconversion at 8 months was remarkably high. SBB-ELISA was more sensitive in lower titre ranges.
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| http://dx.doi.org/10.1016/s0264-410x(97)00048-0 | DOI Listing |
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