The Levene model in 7-day-old rats is the most often used model of hypoxia-ischaemia (HI) in immature animals. The rat central nervous system is immature at birth and corresponds neurodevelopmentally to the term human infant during the second postnatal week. The Levene model of HI differs from clinical asphyxia with respect to the unilateral distribution of brain injury and lack of multi-organ dysfunction. Furthermore, it does not allow cardiovascular monitoring or repeated blood sampling. On the other hand, the progressive nature of HI bears many similarities to birth asphyxia with regard to blood flow changes and cellular metabolic derangements. The model is well characterized, easy to carry out and the low cost allows inclusion of a sufficient number of animals for dose-response evaluation of neuroprotective agents. In addition, it provides the unique opportunity of long-term evaluation of neuropathological and functional outcome.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1651-2227.1997.tb18353.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The effect of a single dose of Mk-801 use on adult brain tissue after an experimental head trauma model applied in immature rats.
Neurol Res
February 2025
Department of Physiology, Faculty of Medicine, Izmir Democracy University, Izmır, Turkey.
Objective: Within the scope of this research, the long-term effects of experimental blunt head trauma on immature rats and MK-801 administered acutely after trauma on the brain tissue will be examined. In addition, the impact of trauma and MK-801 on Nestin and CD133, which are essential stem cells, will be evaluated by immunohistochemical and ELISA methods.
Methods: In this study, the contusion trauma model was used.
Maternal milk cell components are uptaken by infant liver macrophages via extracellular vesicle mediated transport.
FASEB J
January 2025
Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Milk is a multifaceted biofluid that is essential for infant nutrition and development, yet its cellular and bioactive components, particularly maternal milk cells, remain understudied. Early research on milk cells indicated that they cross the infant's intestinal barrier and accumulate within systemic organs. However, due to the absence of modern analytical techniques, these studies were limited in scope and mechanistic analysis.
View Article and Find Full Text PDFEffects of DHEA and DHEAS in Neonatal Hypoxic-Ischemic Brain Injury.
Antioxidants (Basel)
December 2024
Department of Pediatrics II (Neonatology), Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Neonatal brain injury remains a significant issue with limited treatment options. This study investigates the potential of the endogenous neurosteroid dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) as neuroprotective agents, building on evidence of their mechanisms in adult brain injury models. The primary objective was to evaluate their neuroprotective and anti-oxidative properties in a mouse model of neonatal hypoxic-ischemic brain injury.
View Article and Find Full Text PDFFirst report of as a causal agent of post-harvest disease of watermelons () in Brazil.
Plant Dis
December 2024
Universidade Federal Rural do Semi-Arido, Ciências Agronômicas e Florestais, Mossoro, Rio Grande do Norte, Brazil;
Watermelon (), it's an important fruit in Brazil, producing 1.9 million ton/year, occupies the fifth place in the world, (FAO, 2022), but post-harvest diseases are a major limitation, leading to losses of up to 15% (Balasubramaniam et al. 2023).
View Article and Find Full Text PDFAntioxidant System Activity in Roots and Shoots of Bean Cultivars in Response to Seed Treatment with Auxin as a Potential Model of Interaction with Endophytic Bacteria.
Plants (Basel)
November 2024
Bashkir Research Institute of Agriculture, Subdivision of the Ufa Federal Research Center of the Russian Academy of Sciences, R. Zorge Str. 19, 450059 Ufa, Russia.
Plant growth-promoting endophytic bacteria (PGPEB), producing auxins, are offered for a promising eco-friendly crop production. Precise bacterial strain selection is essential to ensure consistent and effective plant growth and resilience. Creating a model for the optimal dose-dependent interactions between PGPEB and hosts is necessary for understanding the mechanisms of high-precision selection of the inoculant composition to enhance bacterial preparations' efficacy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!