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Occupational noise, work-related stress, and teachers' health in the French CONSTANCES study.
Noise Health
January 2025
MGEN Foundation for Public Health, Paris, France.
Objective: Besides psychosocial stressors, teachers are exposed to disturbing noise at work, such as students' irrelevant speech. Few studies have focused on this issue and its health consequences. We explored occupational noise exposure among teachers within the French workforce and analyzed how noise and work-related stress are related to their health.
View Article and Find Full Text PDFAre we systematically overdosing women? Revisiting standardized contrast protocols for thoracoabdominal CT scans.
Eur Radiol
January 2025
Department of Diagnostic and Interventional Radiology, University Hospital Augsburg, Augsburg, Germany.
Objectives: The purpose of this study was to evaluate whether the iodine contrast in blood and solid organs differs between men and women and to evaluate the effect of BMI, height, weight, and blood volume (BV) on sex-specific contrast in staging CT.
Materials And Methods: Patients receiving a venous-phase thoracoabdominal Photon-Counting Detector CT (PCD-CT) scan with 100- or 120-mL CM between 08/2021 and 01/2022 were retrospectively included in this single-center study. Image analysis was performed by measuring iodine contrast in the liver, portal vein, spleen, left atrium, left ventricle, pulmonary trunk, ascending and descending aorta on spectral PCD-CT datasets.
Background: With the approval of several anti-amyloid antibodies and a robust pipeline of new amyloid-based therapies, attention turns towards questions related to real-world clinical practice. Here we explore the impact of several biological pathways on the amyloid biomarker response of AD patients using a Quantitative Systems Pharmacology (QSP) approach with the ultimate objective to find measurable biomarkers for responder identification.
Method: Using a well-validated QSP biophysically realistic model of amyloid aggregation, we performed sensitivity analysis to identify key drivers of amyloid biomarkers both in a longitudinal observational context and after treatment with specific amyloid antibodies.
Biomarkers.
Alzheimers Dement
December 2024
Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Background: Producing speech is a cognitively complex task and can be collected through devices such as handheld recorders, tablets, and smartphones. Digital voice data can also capture information at a granular millisecond-level precision and serve as a widespread tool to collect cognitively relevant data in almost any diverse real-world environments. Digital voice recordings of spoken responses to neuropsychological test questions have been collected through the Framingham Heart Study (FHS) since 2005.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
University of California, Davis School of Medicine, Sacramento, CA, USA.
Background: Most studies on the associations between traffic related air pollution (TRAP), cognition, and dementia focus on particulate matter (PM) 2.5, are cross-sectional and based on non-Hispanic White (NHW) individuals. Less is known about how exposure to ultrafine PM (UFPM) affects cognition in racially/ethnically diverse cohorts.
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