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Resting beat-to-beat blood pressure variability in humans: role of alpha-1 adrenergic receptors.
Clin Auton Res
January 2025
Department of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.
Purpose: Resting beat-to-beat blood pressure variability is a strong predictor of cardiovascular events and mortality. However, its underlying mechanisms remain incompletely understood. Given that the sympathetic nervous system plays a pivotal role in cardiovascular regulation, we hypothesized that alpha-1 adrenergic receptors (the main sympathetic receptor controlling peripheral vasoconstriction) may contribute to resting beat-to-beat blood pressure variability.
View Article and Find Full Text PDFPrognostic value of beat-to-beat blood pressure variability parameters in patients after mechanical thrombectomy.
Hypertens Res
December 2024
Stroke Center, Department of Neurology, The First Hospital of Jilin University, Chang Chun, China.
The relationship of beat-to-beat blood pressure variability (BPV) with prognosis after mechanical thrombectomy (MT) is unclear. Consecutive patients with acute ischemic stroke with large vessel occlusion treated with and without MT matched 1:1 by age, sex, and National Institutes of Health Stroke Scale were included. Beat-to-beat BPV was calculated for both systolic (SBP) and diastolic blood pressure (DBP) as standard deviation, coefficient of variation, successive variation (SV), and average real variability (ARV) at 24-72 h after MT.
View Article and Find Full Text PDFBaroreflex Sensitivity and Long-Term Dementia Risk in Older Adults.
Hypertension
February 2025
Department of Epidemiology (M.K., A.H., F.J.W., M.A.I.), Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Background: Increased blood pressure (BP) variability is linked to dementia risk, but the relationship between baroreflex sensitivity (BRS), a fundamental mechanism for maintaining stable BP, and dementia risk is undetermined.
Methods: We tested the hypothesis that impaired BRS is associated with increased dementia risk in 1819 older adults (63% women; age, 71.0±6.
Ectopic Atrial Beats May Cause a ZigZag Pattern at Intrapartum Recording of the Fetal Heart Rate Using Fetal Scalp Electrode.
Fetal Diagn Ther
December 2024
Department of Medicine and Surgery, Obstetrics and Gynecology Unit, University of Parma, Parma, Italy.
Introduction: Fetal scalp electrode (FSE) is considered the gold standard for the intrapartum monitoring of the fetal heart rate (FHR) being associated with the lowest rate of signal loss and artifacts including the recording of the maternal heart rate. FSE acquires a fetal electrocardiogram and evaluates the time intervals between successive R waves. As such, it allows the recording of the beat-to-beat fluctuation of the FHR.
View Article and Find Full Text PDFBlunted Exercise Pressor Response to Isometric Knee Extension and Post Exercise Ischemia in Individuals with Down Syndrome.
Med Sci Sports Exerc
December 2024
Integrative Physiology Laboratory, Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL.
Introduction: Individuals with Down syndrome (DS) exhibit autonomic dysfunction, which contributes to reduced work capacity. The metaboreflex produces exercise-induced sympathoexcitation and can be assessed via post-exercise muscle ischemia (PEMI). Blunted sympathoexcitation is common in individuals with DS and contributes to the physiological basis for reduced work capacity observed this population, but the influence of the metaboreflex is unknown.
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