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Pneumococcal pneumonia is driven by increased bacterial turnover due to bacteriocin-mediated intra-strain competition.
Commun Biol
December 2024
Department of Microbiology, New York University School of Medicine, New York, NY, USA.
Using chromosomal barcoding, we observed that >97% of the Streptococcus pneumoniae (Spn) population turns over in the lung within 2 days post-inoculation in a murine model. This marked collapse of diversity and bacterial turnover was associated with acute inflammation (severe pneumococcal pneumonia), high bacterial numbers in the lungs, bacteremia, and mortality. Intra-strain competition mediated by the blp locus, which expresses bacteriocins in a quorum-sensing-dependent manner, was required for each of these effects.
View Article and Find Full Text PDFQingfei Yin alleviates Streptococcus pneumoniae pneumonia by promoting complete autophagy to suppress necroptosis.
Phytomedicine
January 2025
Pediatric Respiratory Medicine Department, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, PR China. Electronic address:
Background: Bacterial pneumonia is most prevalent among all pneumonia types, with Streptococcus pneumoniae being the main pathogen. Qingfei Yin (QFY) is a traditional Chinese medicine formula used in the clinical treatment of bacterial pneumonia. Previous studies have confirmed the multi-target and -effect characteristics of QFY in treating S.
View Article and Find Full Text PDFForsythoside B, the active component of Frosythiae fructuse water extract, alleviates Streptococcus pneumoniae virulence by targeting pneumolysin.
J Appl Microbiol
October 2024
Children's Diagnosis and Treatment Center, The Affiliated Hospital to Changchun University of Chinese Medicine, No. 185, Shenzhen Street, Nanguan District, Changchun, Jilin 130022, China.
Article Synopsis
- Forsythoside B is being studied for its potential to treat Streptococcus pneumoniae infections by inhibiting pneumolysin, which is a toxin that can harm cells.
- Experiments demonstrated that Forsythoside B successfully inhibited the activity of pneumolysin, protected lung cells from damage, and did not interfere with the growth of the bacteria.
- In mouse models, it improved survival rates and reduced lung inflammation, highlighting its promise as a treatment for pneumococcal pneumonia.
Clinical Characteristics of Children with Acute Post-Streptococcal Glomerulonephritis and Re-Evaluation of Patients with Artificial Intelligence.
Medeni Med J
September 2024
Konya City Hospital, Clinic of Pediatric Nephrology, Konya, Türkiye.
Article Synopsis
- - The study investigates the use of AI, specifically ChatGPT, in the follow-up care of children diagnosed with acute post-streptococcal glomerulonephritis (APSGN), a common kidney condition caused by streptococcus infection.
- - Researchers analyzed 11 pediatric patients with APSGN, noting their clinical characteristics and evaluating the accuracy of ChatGPT's responses to specific medical questions about the condition and its management.
- - Findings suggest that ChatGPT provides accurate information regarding APSGN and can assist clinicians in decision-making and treatment planning for affected patients, potentially improving patient management.
Molecular characterization of a novel putative pathogen, sp. nov., isolated from sputum culture.
Microbiol Spectr
October 2024
Department of Microbiology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Unlabelled: Reports of novel species of α-hemolytic have increased recently. However, limited information exists regarding the pathogenicity of these species, with the exception of and . In this study, a quinolone-resistant α- strain, MTG105, was isolated from the sputum of a patient with pneumonia.
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