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Episodic and associative memory from spatial scaffolds in the hippocampus.
Nature
January 2025
Department of Brain and Cognitive Sciences and McGovern Institute, MIT, Cambridge, MA, USA.
Hippocampal circuits in the brain enable two distinct cognitive functions: the construction of spatial maps for navigation, and the storage of sequential episodic memories. Although there have been advances in modelling spatial representations in the hippocampus, we lack good models of its role in episodic memory. Here we present a neocortical-entorhinal-hippocampal network model that implements a high-capacity general associative memory, spatial memory and episodic memory.
View Article and Find Full Text PDFCommon neocortical and hippocampal correlates of Performance errors in a timing task.
J Neurosci
January 2025
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102.
We aimed to identify the neuronal correlates of performance errors in a difficult timing task. Male rats were trained to seek ewards and avoid hocks depending on the position of photic conditioned stimuli (CS- and CS-, respectively). Then, they were exposed to conflict trials where they had to time the interval between the CS-R and CS-S to obtain rewards while avoiding footshocks.
View Article and Find Full Text PDFAdults are capable of either differentiating or integrating similar events in memory based on which representations are optimal for a given situation. Yet how children represent related memories remains unknown. Here, children (7-10 years old) and adults formed memories for separate yet overlapping events.
View Article and Find Full Text PDFTwo key series of discoveries about the hippocampus are described. One is the discovery of hippocampal spatial view cells in primates. This discovery opens the way to a much better understanding of human episodic memory, for episodic memory prototypically involves a memory of where people or objects or rewards have been seen in locations "out there" which could never be implemented by the place cells that encode the location of a rat or mouse.
View Article and Find Full Text PDFHuman hippocampal CA3 uses specific functional connectivity rules for efficient associative memory.
Cell
January 2025
Institute of Science and Technology (ISTA), 3400 Klosterneuburg, Austria. Electronic address:
Our brain has remarkable computational power, generating sophisticated behaviors, storing memories over an individual's lifetime, and producing higher cognitive functions. However, little of our neuroscience knowledge covers the human brain. Is this organ truly unique, or is it a scaled version of the extensively studied rodent brain? Combining multicellular patch-clamp recording with expansion-based superresolution microscopy and full-scale modeling, we determined the cellular and microcircuit properties of the human hippocampal CA3 region, a fundamental circuit for memory storage.
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