Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S0006-3223(97)00227-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The inhibitory effects of pimozide, an antipsychotic drug, on voltage-gated K channels in rabbit coronary arterial smooth muscle cells.
Drug Chem Toxicol
March 2023
Department of Physiology, Kangwon National University School of Medicine, Chuncheon, South Korea.
Pimozide is an antipsychotic drug used to treat chronic psychosis, such as Tourette's syndrome. Despite its widespread clinical use, pimozide can cause unexpected adverse effects, including arrhythmias. However, the adverse effects of pimozide on vascular K channels have not yet been determined.
View Article and Find Full Text PDFEvidence for Protein-Protein Interaction between Dopamine Receptors and the G Protein-Coupled Receptor 143.
Int J Mol Sci
August 2021
Department of Pharmaceutical & Medicinal Chemistry, Pharmaceutical Institute, University of Bonn, D-53121 Bonn, Germany.
Protein-protein interactions between G protein-coupled receptors (GPCRs) can augment their functionality and increase the repertoire of signaling pathways they regulate. New therapeutics designed to modulate such interactions may allow for targeting of a specific GPCR activity, thus reducing potential for side effects. Dopamine receptor (DR) heteromers are promising candidates for targeted therapy of neurological conditions such as Parkinson's disease since current treatments can have severe side effects.
View Article and Find Full Text PDFPimozide augments bromocriptine lethality in prolactinoma cells and in a xenograft model via the STAT5/cyclin D1 and STAT5/Bcl‑xL signaling pathways.
Int J Mol Med
January 2021
Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.
As hyperprolactinemia is observed in patients with bromocriptine‑resistant prolactinoma, prolactin (PRL) has been implicated in the development of bromocriptine resistance. Since PRL primarily mediates cell survival and drug resistance via the Janus kinase‑2 (JAK2)/signal transducer and activator of transcription 5A (STAT5) signaling pathway, the STAT5 inhibitor, pimozide, may inhibit cell proliferation and reverse bromocriptine resistance in prolactinoma cells. In the present study, compared with bromocriptine or pimozide alone, the combination of pimozide and bromocriptine exerted enhanced reduction in cell growth and proliferation, and increased apoptosis and cell cycle arrest in bromocriptine‑resistant prolactinoma cells.
View Article and Find Full Text PDFArticle Synopsis
- * Selective serotonin reuptake inhibitors (SSRIs) have shown effectiveness for PE, while other medications like doxepin and olanzapine also appear beneficial in individual cases.
- * A case study of a 59-year-old male with schizophrenia and severe PE highlighted the successful use of olanzapine alongside another medication, suggesting this combination may be effective for similar patients, meriting further investigation.
Pimozide Inhibits the Human Prostate Cancer Cells Through the Generation of Reactive Oxygen Species.
Front Pharmacol
January 2020
Department of Laboratory Animal Medicine, Research Institute for Veterinary Science, BK21 PLUS Program for Creative Veterinary Science Research, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.
The United States Food and Drug Administration-approved antipsychotic drug, pimozide, has anticancer activities. However, the role of reactive oxygen species (ROS) in its effect on prostate cancer is not well-known. We examined cell proliferation, colony formation, migration, ROS production, and the expression of antioxidant-related genes after treatment of human prostate cancer PC3 and DU145 cells with pimozide.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!