Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor peptide, whereas nitric oxide (NO) is a potent endothelium-derived vasorelaxing factor synthesized from L-arginine by NO synthase (NOS). ET-1 and NO exert many biological actions in a counter-regulatory manner in vascular remodeling and vascular tonus. Furthermore, there exists a close interaction between ET-1 and NO:ET-1 stimulates NO generation, while NO down-regulates the expression of ET-1 gene.
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