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Effect of Dendrobium Officinale on Radioactive Oral Mucositis of Nasopharyngeal Carcinoma and Changes of Oral Microecology.
Integr Cancer Ther
January 2025
Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Objective: To observe the clinical efficacy of Dendrobium officinale in the treatment of radiotherapy-induced oral mucositis in nasopharyngeal carcinoma patients, and to explore its regulating effect on immune function and oral microbiota by comparing immune-related factors and oral microbiota before and after the intervention.
Methods: We conducted a randomized double-blinded controlled trial in Zhejiang Cancer Hospital. Sixty patients with nasopharyngeal cancer combined with radiotherapy-induced oral mucositis were randomly divided into a study group and control group, with 30 cases in each group The study group used compound vitamin B12 solution and Dendrobium tea drink, and the control group simply used compound vitamin B12 solution rinse.
Mesenchymal Stem Cell-Derived Extracellular Vesicles for Regenerative Applications and Radiotherapy.
Cell Transplant
January 2025
School of Basic Medicine Sciences, Shandong Second Medical University, Weifang, China.
Tissue repair is an extremely crucial part of clinical treatment. During the course of disease treatment, surgery, chemotherapy, and radiotherapy cause tissue damage. On the other hand, Normal tissue from accidental or therapeutic exposure to high-dose radiation can cause severe tissue damage.
View Article and Find Full Text PDFEffect of blood oxidative stress indicators on oral mucositis in patients undergoing radiotherapy for nasopharyngeal carcinoma.
Eur J Med Res
November 2024
Department of Stomatology, The First Affiliated Hospital of Hainan Medical University, No. 31 Longhua Road, Haikou, 570102, Hainan, China.
Article Synopsis
- The study explores the relationship between total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-PX), and advanced oxidized protein products (AOPP) levels in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy, focusing on the development of oral mucositis (OM).
- Researchers measured these biomarkers at various points during treatment and categorized patients into severe and non-severe OM groups to observe changes over time.
- Findings indicate that while T-AOC and GSH-PX levels temporarily increased during treatment, they decreased significantly in severe OM patients, alongside consistently rising AOPP levels, with certain risk factors identified as contributing to the severity of OM.
A gelatin/acrylamide-based hydrogel for smart drug release monitoring and radiation-induced wound repair in breast cancer.
Int J Biol Macromol
December 2024
State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China; Zhengzhou Institute of Emerging Industrial Technology, Zhengzhou 450000, China. Electronic address:
Radiotherapy is a common local treatment for breast cancer, and while it is effective in targeting tumor cells, it inevitably causes significant side effects. These include excessive production of reactive oxygen species (ROS), repeated inflammatory, and severe skin ulceration, all of which can hinder the wound healing process. As a result, there is a pressing need for multifunctional medical dressings that can support wound repair following radiotherapy.
View Article and Find Full Text PDFMetal-organic framework-edaravone nanoparticles for radiotherapy-induced brain injury treatment.
Biomaterials
March 2025
Department of Radiology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou 310006, China. Electronic address:
Cranial radiotherapy may cause damage to normal brain tissues and induce cognitive dysfunction, so developing an effective strategy to prevent radiotherapy-induced brain injury is essential. Metal-organic frameworks (MOFs) can be used as vectors for the delivery of neuroprotective drugs due to their high drug loading capacity and low toxicity. In this study, we synthesized MIL-53(Cr) nanoparticles, which were used to deliver edaravone, and modified the surface of the nanoparticles with polyethylene glycol and Angiopep-2 (EDA@MIL-53(Cr)-P/A) to improve their oral bioavailability and ability to cross the blood-brain barrier (BBB).
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