AI Article Synopsis
- The study discusses a case of herpes simplex encephalitis (HSE) in a 5-year-old boy with pontine glioma, highlighting a notable difference in imaging results between two types of SPECT scans.
- Two weeks post-radiation therapy, magnetic resonance imaging revealed a lesion indicative of HSE, which showed increased tracer accumulation on the 99mTc-HMPAO SPECT.
- In contrast, the 99mTc-ECD SPECT demonstrated an initial spike in tracer accumulation that quickly declined, suggesting differing mechanisms for how these tracers are processed in brain tissue.
Article Abstract
In herpes simplex encephalitis (HSE), the authors noted an evident dissociation between the 99mTc-ethyl cysteinate dimer (ECD) and 99mTc-d,l-hexamethyl-propylene-amine oxime (HMPAO) single photon emission computed tomographies (SPECTs). The patient was a 5-year-old boy with diffuse type of pontine glioma, which was treated with hyperfractionated radiotherapy. Two weeks after the completion of radiation therapy, a lesion suggesting that of HSE was noted in the right fronto-temporal region on magnetic resonance images. 99mTc-HMPAO SPECT showed an increased accumulation of the tracer in this lesion. On the 99mTc-ECD dynamic SPECT, an exaggerated accumulation of the tracer was noted within 80 s of administration, followed by a rapid drop in the accumulation, resulting in a low accumulation in 10 min. It was assumed that this dissociation was due to the different mechanisms to trap HMPAO and ECD in the brain tissue.
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| http://dx.doi.org/10.1007/s003810050096 | DOI Listing |
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