Cell
Department of Pathology, Kaplan Cancer Center, New York University Medical Center, New York 10016, USA.
Published: August 1997
Many protozoans of the phylum Apicomplexa are invasive parasites that exhibit a substrate-dependent gliding motility. Plasmodium (malaria) sporozoites, the stage of the parasite that invades the salivary glands of the mosquito vector and the liver of the vertebrate host, express a surface protein called thrombospondin-related anonymous protein (TRAP) that has homologs in other Apicomplexa. By gene targeting in a rodent Plasmodium, we demonstrate that TRAP is critical for sporozoite infection of the mosquito salivary glands and the rat liver, and is essential for sporozoite gliding motility in vitro. This suggests that in Plasmodium sporozoites, and likely in other Apicomplexa, gliding locomotion and cell invasion have a common molecular basis.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/s0092-8674(00)80511-5 | DOI Listing |
Unlabelled: Myosin-IC (myo1c) is a class-I myosin that supports transport and remodeling of the plasma membrane and membrane-bound vesicles. Like other members of the myosin family, its biochemical kinetics are altered in response to changes in mechanical loads that resist the power stroke. However, myo1c is unique in that the primary force-sensitive kinetic transition is the isomerization that follows ATP binding, not ADP release as in other slow myosins.
View Article and Find Full Text PDFInt J Syst Evol Microbiol
January 2025
Universit Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Ten novel Gram-negative, aerobic, non-sporulating, yellow-pigmented rod-shaped bacterial strains motile by gliding were isolated from marine organisms/environments in French Polynesia. Three of them designated as 190524A05c, 190524A02b and 190130A14a were retrieved from orbicular batfish () mucus. Online database comparisons using 16S rRNA amplicons resulted in over 95% similarity to the genus .
View Article and Find Full Text PDFISME J
January 2025
Center for Fundamental and Applied Microbiomics, Biodesign Institue, Arizona State University, Tempe, AZ 85287.
The collective surface motility and swarming behavior of microbes play a crucial role in the formation of polymicrobial communities, shaping ecosystems as diverse as animal and human microbiota, plant rhizospheres, and various aquatic environments. In the human oral microbiota, T9SS-driven gliding bacteria transport non-motile microbes and bacteriophages as cargo, thereby influencing the spatial organization and structural complexity of these polymicrobial communities. However, the physical rules governing the dispersal of T9SS-driven bacterial swarms are barely understood.
View Article and Find Full Text PDFNat Phys
October 2024
Dept. of Chemical Engineering, Stanford University, Palo Alto, CA USA.
During host infection, and related unicellular parasites move using gliding, which differs fundamentally from other known mechanisms of eukaryotic cell motility. Gliding is thought to be powered by a thin layer of flowing filamentous (F)-actin sandwiched between the plasma membrane and a myosin-covered inner membrane complex. How this surface actin layer drives the various gliding modes observed in experiments-helical, circular, twirling and patch, pendulum or rolling-is unclear.
View Article and Find Full Text PDFMicrobiol Spectr
January 2025
Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.