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Metagenomic characterization of viruses in the serum of children with newly diagnosed cancer.
J Clin Virol
December 2024
Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address:
Background And Objectives: A large cohort of pediatric patients with various forms of childhood cancer was investigated for the presence of viruses using metagenomics. A total of 476 patient samples, collected between 1989 and 2018, were analyzed, representing various pediatric oncological diagnoses and a control group of non-malignant diagnoses.
Study Design: The study was carried out using metagenomic sequencing of serum samples.
A Case of Persistent Human Pegivirus Infection in Two Separate Pregnancies of a Woman.
Microorganisms
September 2022
Division of Pediatric Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Human pegivirus (HPgV) is best known for persistent, presumably non-pathogenic, infection and a propensity to co-infect with human immunodeficiency virus or hepatitis C virus. However, unique attributes, such as the increased risk of malignancy or immune modulation, have been recently recognized for HPgV. We have identified a unique case of a woman with high levels HPgV infection in two pregnancies, which occurred 4 years apart and without evidence of human immunodeficiency virus or hepatitis C virus infection.
View Article and Find Full Text PDFThe Second Human Pegivirus, a Non-Pathogenic RNA Virus with Low Prevalence and Minimal Genetic Diversity.
Viruses
August 2022
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
(HPgV-2) is a virus discovered in the plasma of a (HCV)-infected patient in 2015 belonging to the of the family . HPgV-2 has been proved to be epidemiologically associated with and structurally similar to HCV but unrelated to HCV disease and non-pathogenic, but its natural history and tissue tropism remain unclear. HPgV-2 is a unique RNA virus sharing the features of HCV and the first human pegivirus (HPgV-1 or GBV-C).
View Article and Find Full Text PDFHuman Pegivirus Type 1: A Common Human Virus That Is Beneficial in Immune-Mediated Disease?
Front Immunol
June 2022
Medicine Service, Iowa City Veterans Administration Healthcare, Iowa City, IA, United States.
Two groups identified a novel human flavivirus in the mid-1990s. One group named the virus hepatitis G virus (HGV) and the other named it GB Virus type C (GBV-C). Sequence analyses found these two isolates to be the same virus, and subsequent studies found that the virus does not cause hepatitis despite sharing genome organization with hepatitis C virus.
View Article and Find Full Text PDFTissue presentation of human pegivirus infection in liver transplanted recipients.
Microb Pathog
June 2022
Department of Epidemiology and Biostatistics, Faculty of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Human pegivirus-1 (HPgV-1) is known for its protective role in HIV co-infected individuals. This immunomodulatory effect raised questions concerning the possible role of HPgV-1 infection and the risk of rejection in liver transplanted patients. We aimed to evaluate the possible protective effect of HPgV-1 on graft outcome of liver transplanted patients.
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