The glycosidic tumor-associated Tn antigen was conjugated to a lysine backbone containing a helper T-cell epitope in order to activate immune responses specific for some types of carcinomas. As opposed to traditional protein conjugates, this multiple antigen glycopeptide (MAG) offers the advantages of the lack of immunogenicity of the polylysine core and of accurate chemical definition. The MAG construction was assembled by conventional solid-phase peptide synthesis. The analysis of its antigenicity demonstrated that the Tn antigen on the MAG is recognized by Tn-specific monoclonal antibodies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1399-3011.1997.tb01171.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The emerging of emergent SARS-CoV-2 subvariants has reduced the protective efficacy of COVID-19 vaccines. Therefore, novel COVID-19 vaccines targeting these emergent variants are needed. We designed and prepared CoV072, an mRNA-based vaccine against SARS-CoV-2 Omicron (EG.
View Article and Find Full Text PDFMulti-epitope vaccines: a promising strategy against viral diseases in swine.
Front Cell Infect Microbiol
December 2024
School of Basic Medical Sciences, Binzhou Medical University, Yantai, China.
Viral infections in swine, such as African swine fever (ASF), porcine reproductive and respiratory syndrome (PRRS), and foot-and-mouth disease (FMD), have a significant impact on the swine industry. Despite the significant progress in the recent efforts to develop effective vaccines against viral diseases in swine, the search for new protective vaccination strategy remains a challenge. The antigenic epitope, acting as a fundamental unit, can initiate either a cellular or humoral immune response.
View Article and Find Full Text PDFH and B Blood Antigens Are Essential for In Vitro Replication of GII.2 Human Norovirus.
Open Forum Infect Dis
January 2025
Department of Microbiology and Immunology, School of Pharmaceutical Sciences, Wakayama Medical University, Wakayama, Japan.
Background: Human norovirus (HuNoV) is a major cause of enteric infectious gastroenteritis and is classified into several genotypes based on its capsid protein amino acid sequence and nucleotide sequence of the polymerase gene. Among these, GII.4 is the major genotype worldwide.
View Article and Find Full Text PDFOvarian adenomyoma: a case report.
BMC Womens Health
January 2025
Gynecology, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Introduction: Ovarian adenomyoma is a rare gynecological tumor with a high misdiagnosis rate, leading many patients to undergo unnecessary surgeries that may affect fertility. Menstrual abdominal pain is the most common symptom, and auxiliary examinations often cannot clarify its nature. It often relies on intraoperative diagnosis, and surgical resection can achieve good therapeutic effects.
View Article and Find Full Text PDFPatient reported outcomes with earlier use of chimeric antigen receptor-T cell therapy in multiple myeloma.
Lancet Haematol
January 2025
Department of Oncology, McMaster University, Hamilton, ON, Canada. Electronic address:
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!