AI Article Synopsis
- The study focused on rabbits with significant heart artery blockage to understand the effects of cardiac glycosides.
- It was found that the heart's response to these drugs was not influenced by the levels of catecholamines (stress hormones) present.
- The use of propranolol, a medication that blocks certain heart receptors, inhibited the positive effects of a cardiac glycoside on weak heart muscle.
Article Abstract
The object of study were rabbits who had been subjected to ligation of 3 or 4 large branches of the left descending coronary artery 14-20 days before the experiment. In experiments with surgical desympathization of the heart it was established that the inotropic effect of cardiac glycosides did not depend on the concentration of catecholamines in the myocardium. In stimulation of adrenergic structures of the posterior hypothalamus attended with an increase in sympathetic innervation of the cardiovascular system the cardiotoxic threshold of cardiac glycosides was considerably reduced. Propranolol (Inderal) administered in a dose which blocks the beta-adrenergic apparatus of the heart prevents the development of the positive inotropic effect of therapeutic doses of strophanthin K on a hypodynamic left ventricular myocardium.
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