The effect of prostaglandin E1 (PGE1) on the cardiovascular system of the dog has been studied in experiments with anesthetized dogs. After intravenous injections of PGE1 (5 microgram/kg) arterial hypotension, tachycardia, increase of cardiac output, increase of myocardial contractility were observed. PGE1 induced dilatation of pulmonary vessels. Peripheral resistance reduced. The work of the left ventricle after PGE1 injection underwent two-phase changes: it increased for a short period of time and then reduced. The work of the right ventricle was activated. PGE1 caused a significant increase of the volume flow rate in the coronary (44%), femoral (83%) and superior mesenteric (59%) arteries.
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