The effect of synthetic peptide ACTH4-10 on the course of healing of an experimental wound of the rabbit cornea was studied. Daily subconjunctival injections of the drug in a dose of 10(-8) M for 25 days boosted the migration of leukocytes and macrophages and increased the interstitial and keratocyte proteolysis during the first 10 days of the experiment. Subsequent follow-up showed manifest proliferation of fibroblasts and formation of fibrosis. These data demonstrate expressed effect of synthetic ACTH4-10 on the course of the inflammatory and regeneratory processes in the cornea after partial keratectomy and prove the possibility of short-term local therapy with this peptide as an agent improving corneal wound healing during the initial phases.
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Antistress effect of Semax in the course of recovery of spleen lymphoid structures after the stress in rats with different behavioral activity.
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IM Sechenov First Moscow State Medical University, PK Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia.
We studied the effect of antistress peptide Semax, an ACTH4-10 analogue, on the cellular composition of spleen lymphoid structures in Wistar rats with different stress tolerance in the course of post-stress recovery (days 1, 3, 14, and 30). Preliminary administration of Semax alleviates stress-induced proliferation of macrophages and destructive processes in functionally active zones of the rat spleen on days 1, 3, and 14 after the stress exposure, which attests to its capacity to reduce the adverse effects of 1-h stress load on proliferation of macrophages and destructive processes in functionally active zones of this organ.
View Article and Find Full Text PDF[Effect of ACTH4-10 on the course of inflammatory and regeneration processes in the rabbit cornea].
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August 1997
NII of Eye Diseases, RAMN, Moscow.
The effect of synthetic peptide ACTH4-10 on the course of healing of an experimental wound of the rabbit cornea was studied. Daily subconjunctival injections of the drug in a dose of 10(-8) M for 25 days boosted the migration of leukocytes and macrophages and increased the interstitial and keratocyte proteolysis during the first 10 days of the experiment. Subsequent follow-up showed manifest proliferation of fibroblasts and formation of fibrosis.
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