We report a morphological and immunohistochemical study of a case of pure alveolar rhabdomyosarcoma of the uterus in an 80-year-old woman. The diagnostic clues were the characteristic "alveolar" pattern of growth, the evidence of cross-striations in strap or elongated cells with abundant eosinophilic cytoplasms, the presence of multinucleated cells with peripherally placed "wreathlike" nuclei, and the expression of muscular antigens by the tumor cells. A thorough sampling of the tumor excluded areas of other types of heterologous or homologous sarcomas or the presence of coexisting adenoma or carcinoma. The other immunohistochemical data showed a high proliferative rate as well as a high rate of p53 overexpression in the small poorly differentiated rhabdomyoblasts. Interestingly, the large differentiated rhabdomyoblasts expressed CA-125, the antigenic determinant of nonmucinous epithelial ovarian tumors. The clinical course was very aggressive: the patient died 5 months after surgery because of disease progression. The pertinent literature is discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1006/gyno.1997.4742 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Toxic Effects of Petroleum Diesel, Biodiesel, and Renewable Diesel Exhaust Particles on Human Alveolar Epithelial Cells.
J Xenobiot
October 2024
Department of Public Health and Clinical Medicine, Umeå University, 90187 Umeå, Sweden.
The use of alternative diesel fuels has increased due to the demand for renewable energy sources. There is limited knowledge regarding the potential health effects caused by exhaust emissions from biodiesel- and renewable diesel-fueled engines. This study investigates the toxic effects of particulate matter (PM) emissions from a diesel engine powered by conventional petroleum diesel fuel (SD10) and two biodiesel and renewable diesel fuels in vitro.
View Article and Find Full Text PDFEnhanced alveolar ridge preservation with hyaluronic acid-enriched allografts: a comparative study of granular allografts with and without hyaluronic acid addition.
Int J Implant Dent
October 2024
Department of Engineering & IT, Carinthia University of Applied Sciences, Europastraße 4, Villach, 9524, Austria.
Article Synopsis
- Ridge preservation is important for maintaining alveolar ridge volume and improving dental implant outcomes, and this study investigates the effect of adding hyaluronic acid to allografts used for this purpose.
- In a study of 40 patients, those receiving allogeneic bone substitutes with hyaluronic acid experienced significantly less vertical height loss and graft shrinkage compared to those who received allografts without it.
- The findings indicate that adding hyaluronic acid to allografts leads to better graft stability and increased bone density, enhancing the success of ridge preservation after tooth extraction.
Fibroblast activation protein is a cellular marker of fibrotic activity in canine idiopathic pulmonary fibrosis.
Front Vet Sci
July 2024
Department of Companion Animal Clinical Sciences, Fundamental and Applied Research for Animals and Health (FARAH), Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
Article Synopsis
- Canine idiopathic pulmonary fibrosis (CIPF) is a serious lung disease primarily affecting elderly West Highland white terriers and is linked to respiratory failure, with unknown causes.
- * The study aimed to assess the expression of fibroblast activation protein (FAP) in lung biopsies from CIPF-infected dogs and evaluate its potential as a biomarker for fibrosis activity.
- * Results showed that while FAP levels were low in the blood of affected dogs, FAP expression was significantly higher in lung tissues with active fibrosis, suggesting its role in monitoring disease severity.
Pulmonary Alveolar Proteinosis-Like Pathological Changes Mimicking Lung Adenocarcinoma in Situ.
Tohoku J Exp Med
December 2024
Department of Anatomic Pathology, Tohoku University Graduate School of Medicine.
An enlarging ground-glass nodule (GGN) in the lungs closely resembles the characteristic appearance of a well differentiated lung adenocarcinoma or adenocarcinoma in situ (AIS). Herein, we present an unusual case characterized by clinical features suggestive of AIS but pathologically confirmed as exhibiting pulmonary alveolar proteinosis (PAP)-like changes. Patients with enlarging pure GGNs warrant consideration for diagnostic and curative surgery.
View Article and Find Full Text PDFEpidemiology and antimicrobial resistance of spp. in the United Arab Emirates: a retrospective analysis of 12 years of national antimicrobial resistance surveillance data.
Front Public Health
July 2024
Department of Pathology and Infectious Diseases, Khalifa University, Abu Dhabi, United Arab Emirates.
Article Synopsis
- * A 12-year study in the UAE analyzed over 8,000 non-duplicate MTB complex isolates, primarily from respiratory samples, revealing that most patients were non-nationals from Asian countries, particularly India and Pakistan.
- * The study found low levels of drug resistance, with 2.8% of MTB isolates being rifampicin-resistant and a slight upward trend in resistance observed over the years.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!