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Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gastric cancer: a 10-year single center experience.
World J Surg Oncol
February 2025
Department of Surgical Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Background: The rationale behind the use of HIPEC involves targeted elimination of microscopic peritoneal metastasis, a common route for GCa dissemination, thereby improving the overall survival and reducing recurrences. Moreover, the reasoning behind the use of IORT is enhanced loco-regional control and, therefore, reducing recurrence rates.
Methods: From February 2013 to June 2023, all GCa patients who underwent HIPEC plus IORT during surgery were included in this study.
Intraoperative radiotherapy IORT applicators for treatment of small skin lesions a phantom and planning study.
Sci Rep
February 2025
Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
Radiation therapy is actively utilized for superficial lesions. External beam radiotherapy for cutaneous lesions utilizes electrons with low transmittance. Conventional electron beam therapy uses Cerrobend blocks for field shaping; however, the Intraoperative Radiotherapy (IORT) applicator offers superior dosimetric characteristics.
View Article and Find Full Text PDFLong term effectiveness of intraoperative radiotherapy given as a boost in adjuvant treatment for oral cavity cancers.
Sci Rep
February 2025
Maria Sklodowska-Curie National Research Institute of Oncology, Branch Gliwice, Gliwice, Poland.
The oral cancer treatment of choice is surgical excision with an organ preservation, if it is possible. Radiation therapy is commonly used as a postoperative treatment. Delivering radiation dose during surgery, defined as intraoperative radiotherapy (IORT), can be very useful especially in case of high risk of recurrence or where gross or macroscopic residual disease are present.
View Article and Find Full Text PDFSafety and efficacy of intraoperative radiation therapy using a low-energy X-ray source for resectable pancreatic cancer: an interim evaluation of an ongoing prospective phase II study.
Cancer Biol Med
January 2025
Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Objective: The role of intraoperative radiation therapy (IORT) in the management of resectable pancreatic cancer (RPC) remains unclear. To date, the application of IORT using a low-energy X-ray source has not been extensively investigated. Therefore, this study was conducted to evaluate the safety and efficacy of IORT using a 50 kV X-ray source in treating RPC.
View Article and Find Full Text PDFThe effect of intraoperative radiotherapy in musculoskeletal malignancy: A population study from US SEER database.
J Cancer
January 2025
Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute &Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin 300060, China.
The aim of our study was to explore the effect of IORT on survival outcome of patients with musculoskeletal malignancy. The prognostic factors of patients with IORT treatment were also identified in this study. The retrospective analysis was conducted based on the Surveillance, Epidemiology, and End Results (SEER) database spanning from 2000 to 2020.
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