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The multifaceted role of the inferior colliculus in sensory prediction, reward processing, and decision-making.
Elife
January 2025
Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
The inferior colliculus (IC) has traditionally been regarded as an important relay in the auditory pathway, primarily involved in relaying auditory information from the brainstem to the thalamus. However, this study uncovers the multifaceted role of the IC in bridging auditory processing, sensory prediction, and reward prediction. Through extracellular recordings in monkeys engaged in a sound duration-based deviation detection task, we observed a 'climbing effect' in neuronal firing rates, indicative of an enhanced response over sound sequences linked to sensory prediction rather than reward anticipation.
View Article and Find Full Text PDFMeasurement of inferior colliculus volume based on MRI image stacks and its relationship with age and hearing status.
PLoS One
January 2025
Department of Otolaryngology, University Hospital Regensburg, Regensburg, Germany.
The inferior colliculus is a key nucleus in the central auditory pathway, integrating acoustic stimuli from both cochleae and playing a crucial role in sound localization. It undergoes functional and structural development in childhood and experiences age-related degeneration later in life, contributing to the progression of age-related hearing loss. This study aims at finding out, whether the volume of the human inferior colliculus can be determined by analysis of routinely performed MRIs and whether there is any age-related variation.
View Article and Find Full Text PDFFunctional and Structural Changes in the Inner Ear and Cochlear Hair Cell Loss Induced by Hypergravity.
Int J Mol Sci
January 2025
Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Inha University, Incheon 22332, Republic of Korea.
Gravitational changes have been shown to cause significant abnormalities in various body systems, including the cardiovascular, immune, vestibular, and musculoskeletal systems. While numerous studies have examined the response of the vestibular system to gravitational stimulation, research on functional changes in the peripheral inner ear remains limited. The inner ear comprises two closely related structures: the vestibule and cochlea.
View Article and Find Full Text PDFLateral olivocochlear neurons modulate cochlear responses to noise exposure.
Proc Natl Acad Sci U S A
January 2025
Department of Neurobiology, Harvard Medical School, Boston, MA 02115.
The sense of hearing originates in the cochlea, which detects sounds across dynamic sensory environments. Like other peripheral organs, the cochlea is subjected to environmental insults, including loud, damage-inducing sounds. In response to internal and external stimuli, the central nervous system directly modulates cochlear function through olivocochlear neurons (OCNs), which are located in the brainstem and innervate the cochlear sensory epithelium.
View Article and Find Full Text PDFNormative Values of Brainstem Auditory-Evoked Responses in Sheep.
Brain Sci
January 2025
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8006 Zurich, Switzerland.
The brainstem auditory-evoked response (BAER) is an established electrophysiological measure of neural activity from the auditory nerve up to the brain stem. The BAER is used to diagnose abnormalities in auditory pathways and in neurophysiological human and animal research. However, normative data for BAERs in sheep, which represent an adequate large animal model for translational and basic otological research, are lacking.
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