Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Heterotypic spheroids as a strategy for 3D culture of cryopreserved primary human hepatocytes in stirred-tank systems.
SLAS Discov
January 2025
iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12 2781-901 Oeiras, Portugal; ITQB NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Av. Republica, 2780-157, Oeiras, Portugal. Electronic address:
Primary human hepatocytes (PHHs) are the preferred cell source to address liver function. Despite originating from the native tissue, one of the bottlenecks when using primary material is the donor-to-donor variability. Cryopreserved PHHs offer a high number of cells from the same donor and standardization of cell isolation and cryopreservation procedures, mitigating some of the inter-donor variability.
View Article and Find Full Text PDFEarly-Branching Cyanobacteria Grow Faster and Upregulate Superoxide Dismutase Activity Under a Simulated Early Earth Anoxic Atmosphere.
Geobiology
December 2024
Department of Microbiology, University of Kaiserslautern-Landau RPTU, Kaiserslautern, Germany.
The evolution of oxygenic photosynthesis during the Archean (4-2.5 Ga) required the presence of complementary reducing pathways to maintain the cellular redox balance. While the timing of the evolution of superoxide dismutases (SODs), enzymes that convert superoxide to hydrogen peroxide and O, within bacteria and archaea is not resolved, the first SODs appearing in cyanobacteria contained copper and zinc in the reaction center (CuZnSOD).
View Article and Find Full Text PDFRCA-mediated tandem assembly of DNA molecular probes on lipid particles surface for efficient detection and imaging of intracellular miRNA.
Biosens Bioelectron
March 2025
Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, Cixi Biomedical Research Institute, School of Laboratory Medicine and Life sciences, Wenzhou Medical University, Wenzhou, 325035, China. Electronic address:
Article Synopsis
- Aberrant microRNA (miRNA) expression is linked to various cancers, creating the need for effective detection methods for cancer diagnosis and therapy.
- The study introduces a novel approach by creating cholesterol-DNA micelles attached to amplification products, allowing for efficient signal amplification through a designed nanoprobe (RC-HCR) that detects miRNA levels in living cells.
- The RC-HCR probe demonstrated high sensitivity (1 fM detection limit), wide quantification range, and selectivity in distinguishing wild-type miR-21 from its variants, showcasing its potential as a powerful tool for early cancer diagnosis.
Stirring the Pot: Antoine Baumé, Josiah Wedgwood, Pierre-Louis Guinand, and the Development of Optical Glass.
Ambix
November 2024
Independent Researcher, Briarcliff Manor, NY, USA.
The development of defect-free flint glass for use in telescopes and navigational instruments was a key technological challenge facing European chemists, natural philosophers, and artisans that emerged in the 1750s. In 1805, Pierre-Louis Guinand, a Swiss artisan, invented a fireclay stirrer used to stir molten flint glass to create a homogenous mixture relatively free of defects. In this paper, I show it was not Guinand, but French chemist Antoine Baumé, who first came up with the idea of using a fireclay stirrer.
View Article and Find Full Text PDFLight scattering study of algal floc growth and structure: alum polymeric plant-derived flocculant.
Soft Matter
January 2025
Clarkson University, Department of Chemical & Biomolecular Engineering, 8 Clarkson Avenue, Potsdam, NY 13699, USA.
The flocculation dynamics of algal cultures using alum and aqueous seed extracts as flocculants were analyzed through light scattering and fractal analysis. Floc growth in continuously stirred suspensions, with cell densities ranging from 200 to 800 μg L chlorophyll (Chl ), exhibited distinct patterns in fractal dimension () evolution relative to floc size: a smooth, monotonic increase; stochastic increase; and stabilization or leveling off. values ranged from 1.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!