Objective: Quantitative descriptions of form (size and shape) changes are significant to the understanding of the development, treatment planning, and prognosis of patients born with cleft lip and palate. This study compared the results of traditional dental arch form change measurements, such as width, depth, perimeter, and area, with four numeric methods: finite element scaling analysis, macroelement method, Euclidean distance matrix analysis, and conventional least-squares and resistant-fit theta rho Procrustes analyses.
Design: Using tooth cusp landmarks on maxillary study casts, form change measurements of a male with complete bilateral cleft lip and palate at ages 2, 5, and 6 years were made comparing each age to the next older.
Results And Conclusions: With the exception of the 2- to 5-year resistant-fit analysis, all numeric method: 1) provide comparable results, 2) provide more detailed descriptions than do traditional methods, and 3) provide results that correlate well with the reported effects of increased lip pressure due to lip closure surgery. The use of finite-element scaling analysis on study casts is somewhat limited since: 1) there is more than one solution at teeth shared by many finite elements, 2) gross averaging of form change occurs within triangular elements, and 3) solutions can vary with the choice of element location. The use of the macroelement method circumvented the above finite element limitations without compromising finite-element advantages. Procrustes results vary with the chosen superposition algorithm. The choice of the most appropriate Procrustes method required some a priori knowledge of form difference. The large number of results obtained by Euclidean distance matrix analysis and the nongraphic presentation of these results hamper quick interpretation but may be best suited for definitive statistical analysis. The graphic representation of both the magnitude and direction of: 1) landmark displacement in the Procrustes analyses (once size difference is eliminated), and 2) the rate of form change in the macroelement method provide an intuitive appreciation of how and where the casts differ.
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http://dx.doi.org/10.1597/1545-1569_1997_034_0281_contit_2.3.co_2 | DOI Listing |
Neurol Neuroimmunol Neuroinflamm
March 2025
Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt- Universität zu Berlin.
Background And Objectives: Cognitive deficits represent a major long-term complication of anti-leucine-rich, glioma-inactivated 1 encephalitis (LGI1-E). Although severely affecting patient outcomes, the structural brain changes underlying these deficits remain poorly understood. In this study, we hypothesized a link between white matter (WM) networks and cognitive outcomes in LGI1-E.
View Article and Find Full Text PDFCodas
January 2025
Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre - HCPA - Porto Alegre (RS), Brasil.
Purpose: to characterize mastication and electrical activation of the masseter and anterior temporalis muscles in children and adolescents with osteogenesis imperfecta (OI), and relate results to guided occlusion and occlusal interference.
Methods: This observational, analytical cross-sectional study included 22 subjects divided into mild OI (MOI) (type 1) (n=15) and moderate-to-severe OI (MSOI) (types 3, 4, and 5) (n=7) groups. The Orofacial Myofunctional Evaluation with Scores (OMES) form was used to evaluate the clinical aspects of mastication.
Anal Chem
January 2025
School of Molecular and Cellular Biology and Astbury Centre, University of Leeds, Leeds LS2 9JT, U.K.
Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is a powerful technique to interrogate protein structure and dynamics. With the ability to study almost any protein without a size limit, including intrinsically disordered ones, HDX-MS has shown fast growing importance as a complement to structural elucidation techniques. Current experiments compare two or more related conditions (sequences, interaction partners, excipients, conformational states, etc.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Statistics, University of Dhaka, Dhaka, Bangladesh.
Background: Utilization of maternal health care services, specifically, antenatal care services from skilled health providers have been given utmost priority in low- and middle-income countries over years with a view of mitigating complications during pregnancy as well as safeguarding the health and survival of both mother and newborn. However, there is a general tendency of pregnant mothers in Bangladesh of receiving skilled antenatal care (SANC) service once, or even never which refrains us to ensure World Health Organization (WHO) recommended eight plus SANC visits, additionally, to meet Sustainable Development Goal (SDG) number three.
Objectives: The study aims at assessing how the average number of SANC visits taken by the reproductive women in Bangladesh changes over the time in rural and urban areas together with finding out the potential demographic and socio-economic factors associated with SANC visits by addressing possible accumulation of zero and one counts in SANC visits.
J Cell Sci
January 2025
Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Cells form multiple, molecularly distinct membrane contact sites (MCSs) between organelles. Despite knowing the molecular identity of several of these complexes, little is known about how MCSs are coordinately regulated in space and time to promote organelle function. Here, we examined two well-characterized mitochondria-ER MCSs - the ER-Mitochondria encounter structure (ERMES) and the mitochondria-ER-cortex anchor (MECA).
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