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Clinical features of taste disorders in Cronkhite-Canada syndrome: A report of 10 cases.
Chem Senses
December 2024
Department of Otolaryngology-Head and Neck Surgery, Hyogo Medical University, Nishinomiya, Japan.
Article Synopsis
- Cronkhite-Canada syndrome (CCS) is a rare gastrointestinal disorder characterized by taste abnormalities, observed in over 80% of cases, along with various ectodermal issues like nail atrophy and hair loss.
- Ten diagnosed patients underwent assessments for taste function and other symptoms before and after treatment, revealing significant improvements in taste, especially in the anterior tongue.
- The study shows that taste function tests are effective in measuring treatment outcomes, as patients experienced both symptom relief and improved taste function within three months post-treatment.
Efficacy and safety of azathioprine in patients with Cronkhite-Canada syndrome: a case series from Peking Union Medical College Hospital.
BMC Pharmacol Toxicol
December 2024
Department of Gastroenterology, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.
Background: Cronkhite-Canada syndrome (CCS) is a rare non-hereditary chronic inflammatory disease characteristic of gastrointestinal polyps and ectodermal abnormalities. Corticosteroid therapy is the mainstay medication for CCS. Few studies indicated immunosuppressants might be the choices for patients with steroid refractory, steroid dependent or intolerant.
View Article and Find Full Text PDFCronkhite-Canada syndrome: A case report and literature review.
Medicine (Baltimore)
October 2024
Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Article Synopsis
- Cronkhite-Canada syndrome (CCS) is a rare, nonhereditary condition characterized by gastrointestinal polyps, ectodermal changes, and symptoms such as hair loss, skin pigmentation, and malnutrition, predominantly affecting middle-aged and older males.* -
- The case study involves a 72-year-old female who experienced severe gastrointestinal issues, which led to the discovery of multiple polyps through endoscopic examinations after her treatment for intestinal obstruction.* -
- Following a comprehensive treatment plan that included medications and nutritional support, the patient showed significant improvement in symptoms, with reduced diarrhea and a notable decrease in the number and size of polyps upon follow-up examination.*
Case Report: Cronkhite-Canada syndrome: presentation of a pediatric case and review of the literature.
Front Pediatr
September 2024
Department of Gastroenterology, Children's Hospital of Hebei Province, Shijiazhuang, Hebei, China.
Article Synopsis
- Cronkhite-Canada syndrome (CCS) is a rare condition in children that often goes misdiagnosed due to its complex symptoms.
- A case study of a 13-year-old boy highlighted symptoms like persistent diarrhea, vomiting, weight loss, alopecia, and skin changes, with lab tests revealing specific autoimmune indicators.
- The study concludes that thorough assessments, including endoscopic and histological evaluations, are crucial for diagnosing CCS, and treatment with steroids like prednisone can significantly improve symptoms.
Article Synopsis
- Cronkhite-Canada syndrome (CCS) poses diagnostic challenges, necessitating endoscopic exams to check for chronic diarrhea, polyposis, and inflammation in polyps.* -
- A study highlighted seven CCS cases, involving four men and three women aged 48-72, all of whom were Asian, with chronic diarrhea as the main symptom.* -
- CCS carries a significant risk of malignant gastrointestinal conditions, particularly rectal cancer, requiring ongoing surveillance and monitoring through endoscopy.*
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