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Amyloid light chain and amyloid A protein, two types of gastrointestinal amyloidosis.
Rev Esp Enferm Dig
December 2024
Medical Checkup, Naha City Hospital.
We have encountered rare cases of two types of gastrointestinal amyloidosis, amyloid light chain (AL) type and amyloid A protein (AA) type. Case 1: An 83-year-old man developed hematochezia after percutaneous coronary intervention. CT scans showed wall thickening of the colon.
View Article and Find Full Text PDFSalivary gland amyloidosis: Proteomic identification and clinicopathologic characterization of 57 cases.
Hum Pathol
September 2024
Department of Laboratory Medicine and Pathology, Division of Hematopathology, Mayo Clinic, Rochester, MN, 55905, USA.
Article Synopsis
- - Salivary gland amyloidosis is rarely diagnosed, with most research focusing on minor salivary glands instead of major ones; this study analyzed 57 cases using a proteomics method from 2010 to 2022.
- - The biopsies were conducted for various reasons, including suspected amyloidosis, lesions, swelling, and ruling out Sjogren syndrome, with many cases showing concurrent conditions like chronic sialadenitis and different types of lymphoma.
- - The study identified three types of amyloidosis, with the immunoglobulin light chain (AL) type being the most common; understanding the different patterns of amyloid deposits is crucial for effective treatment and prognosis.
Introduction: Amyloid light chain (AL) amyloidosis is a multisystem disease with significant variability in patient presentation. This case describes the presentation and workup of a patient with unique multiorgan involvement on initial presentation.
Case Presentation: A 69-year-old African American male presented with weakness, leg swelling, and shortness of breath.
Clinical clues for suspecting wild-type transthyretin cardiac amyloidosis in patients with monoclonal gammopathy of undetermined significance: a case report.
Egypt Heart J
June 2024
Department of Cardiology, Nagoya University Graduate School of Medicine, 65, Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
Background: Myeloproliferative disorders, including monoclonal gammopathy of undetermined significance (MGUS), are often associated with amyloid light-chain (AL)-type cardiac amyloidosis (CA) but occasionally with wild-type transthyretin (ATTR) CA. In recent years, ATTR amyloidosis has attracted necessity for its reliable diagnosis with the addition of new treatments. Usually, both wild-type ATTR CA and AL-type CA present with marked cardiac hypertrophy, but renal dysfunction is milder in wild-type ATTR amyloidosis than in AL-type amyloidosis.
View Article and Find Full Text PDFCardiac Amyloidosis: A Contemporary Review of Medical and Surgical Therapy.
Curr Cardiol Rev
April 2024
Division of Cardiology, Department of Medicine, Texas Tech Health Science Center, Lubbock, TX 79430, USA.
Amyloidosis is a systemic disease initiated by deposition of misfolded proteins in the extracellular space, due to which multiple organs may be affected concomitantly. Cardiac amyloidosis, however, remains a major cause of morbidity and mortality in this population due to infiltrative /restrictive cardiomyopathy. This review attempts to focus on contemporary medical and surgical therapies for the different types of cardiac amyloidosis.
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