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Background: Regionally anticoagulated continuous renal replacement therapy with citrate is the first choice for critically ill patients with acute kidney injury. If citrate that reaches the patient exceeds the metabolic capacity, metabolic alkalosis will follow. Bicarbonate from the treatment fluids will also reach the patient and add to the bicarbonate load.
View Article and Find Full Text PDFMyeloid-derived suppressor cells (MDSCs) are expanded in cancer patients, have an intrinsic immunosuppressive function, and thus may play a role in resistance to immunotherapy. Ulceration of the melanoma primary is associated with more aggressive disease and is an independent prognostic factor for melanoma-specific survival. However, the underlying factors contributing to this more aggressive phenotype are not completely understood.
View Article and Find Full Text PDFArtificial intelligence for segmentation and classification in lumbar spinal stenosis: an overview of current methods.
Eur Spine J
January 2025
Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.
Purpose: Lumbar spinal stenosis (LSS) is a frequently occurring condition defined by narrowing of the spinal or nerve root canal due to degenerative changes. Physicians use MRI scans to determine the severity of stenosis, occasionally complementing it with X-ray or CT scans during the diagnostic work-up. However, manual grading of stenosis is time-consuming and induces inter-reader variability as a standardized grading system is lacking.
View Article and Find Full Text PDFUnique hierarchical NiFe-LDH/Ni/NiCoS heterostructure arrays on nickel foam for the improvement of overall water splitting activity.
Nanoscale
January 2025
Chongqing Key Laboratory of Inorganic Functional Materials, College of Chemistry, Chongqing Normal University, Chongqing, 401331, PR China.
The development of environmentally friendly, high-efficiency, stable, earth-abundant and non-precious metal-based electrocatalysts with fast kinetics and low overpotential for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) is of exceeding significance but still challenging. Herein, a bifunctional electrode of unique hierarchical NiFe-LDH/Ni/NiCoS/NF (NiFe-LDH = nickel-iron layered double hydroxide and NF = nickel foam) electrocatalytic architecture, which is built up from NiFe-LDH nanosheets, Ni nanoparticles and NiCoS nanoneedles sequentially arrayed on a porous NF substrate, has been prepared by a facile hydrothermal and electrodeposition method. This electrocatalytic architecture is binder-free and its outer NiFe-LDH nanosheets can effectively prevent the oxidation of inner Ni nanoparticles and corrosion of NiCoS nanoneedles during water electrolysis.
View Article and Find Full Text PDFEmerging trends in cervical cancer incidence among younger Taiwanese generations: an urban-rural comparison.
Ann Med
December 2025
College of Public Health, Institute of Health Data Analytics and Statistics, National Taiwan University, Taipei, Taiwan.
Background: Despite global declines in cervical cancer incidence, certain regions observe unexpected rising trends among younger generations.
Methods: This study uses the age-period-cohort model to examine long-term incidence trends of invasive cervical cancer in Taiwan. Data were sourced from the Taiwan Cancer Registry.
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