AI Article Synopsis
- The study explores the connection between Helicobacter pylori infection, gastric emptying delays, and dysmotility-like dyspepsia in patients.
- It involved comparing the gastric emptying rates of 32 healthy volunteers and 72 dyspeptic patients, finding slower emptying in the latter group, especially in those testing positive for H. pylori.
- The results indicate that individuals with delayed gastric emptying (gastroparesis), particularly when combined with H. pylori infection, are at a higher risk of developing dysmotility-like dyspepsia.
Article Abstract
Background: The role of Helicobacter pylori and gastric motility in dysmotility-like dyspepsia is unclear. The aim of this study was to determine whether delayed gastric emptying of indigestible solids and H. pylori infection are associated with dysmotility-like dyspepsia.
Methods: Thirty-two healthy volunteers and 72 patients fulfilling the criteria of dysmotility-like dyspepsia received a gastric emptying test using radiopaque markers, and the H. pylori status was determined by histology.
Results: Twenty-seven percent of volunteers were H. pylori-positive, compared with 32% in the dyspeptic groups (P = NS). Gastric emptying was significantly slower in dyspeptic patients than controls and in H. pylori-positive patients than H. pylori-negative patients. Subjects with gastroparesis have a higher chance of developing dysmotility-like dyspepsia (odds ratio (OR), 2.5) than subjects with normal gastric emptying. Subjects with H. pylori and gastroparesis have an increased likelihood of developing dysmotility-like dyspepsia (OR, 4.3) than if either factor were present alone.
Conclusion: Our data suggest that gastroparesis alone and gastroparesis and H. pylori infection are associated with dysmotility-like dyspepsia.
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| http://dx.doi.org/10.3109/00365529708996517 | DOI Listing |
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