It is known, that the upper airway (oropharyngeal) impedance (Z(op)) influences the measured input impedance of the respiratory system (Zrs). This investigation deals with simple methods reducing the artefact caused by Z(op). The following methods have been examined: (1) Supporting the cheeks with fingers, (2) supporting the cheeks and the floor of the mouth with fingers and (3) using a new mechanical clamp for the cheeks and the floor of the mouth. The effect of these procedures on Zrs, were investigated on two subjects. Also Z(op) has been estimated during a voluntary closure of the glottis (VALSALVA manoeuvre). The impedance has been assessed as well with forced sine shaped oscillations as with the pulsatile technique. All three procedures show, compared to measurements without any support, an increase of the Zrs, especially at high values. The highest increase has been obtained while using the clamp (up to 50%). The varied impedance must be placed in parallel to Zrs, because Z(op) increases even more than Zrs. So, by applying the clamp the subjects is better coupled to the measuring system. The clamp is easy to handle, leads to more exact values, and increases the inter- and intra-individual reproducibility.
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Neurogastroenterol Motil
January 2025
Trisco Foods, Carole Park, Queensland, Australia.
Introduction: Fluid thickeners used in the management of oropharyngeal dysphagia exhibit non-Newtonian shear-thinning rheology, impacting their viscosity during deglutition. This study investigated how the rheological properties of thickened fluids affect pharyngeal swallowing parameters in patients with oropharyngeal motor disorders diagnosed by pharyngeal high-resolution manometry impedance (P-HRM-I).
Methods: Seventy-two patients (18-89 years) referred for P-HRM-I were diagnostically assessed with a 10 mL thin bolus.
Eur J Pediatr
January 2025
Aerodigestive Center, Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
We aimed to determine the prevalence of gastroesophageal reflux disease (GERD) and oropharyngeal dysphagia as explanatory diagnoses, risk factors for acid suppression treatment, and risk factors for repeat hospital visit in infants hospitalized after brief resolved unexplained event (BRUE) using a multicenter pediatric database. We performed a multicenter retrospective database study of infants admitted with BRUE in the Pediatric Health Information System between 2016 and 2021. Data included diagnostic testing, explanatory diagnoses, treatment with acid suppression, and related repeat hospital visits within 6 months.
View Article and Find Full Text PDFJ Pediatr
November 2024
The Innovative Infant Feeding Disorders Research Program, Nationwide Children's Hospital, Columbus, OH; Center for Perinatal Research, The Research Institute, Nationwide Children's Hospital, Columbus, OH; Division of Neonatology, Nationwide Children's Hospital, Columbus, OH; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH. Electronic address:
Curr Opin Gastroenterol
July 2024
Department of Medicine, Brigham and Women's Hospital.
Purpose Of Review: Symptoms/complications related to extraesophageal reflux (EER) are increasingly prevalent presentations and pose significant challenges for clinicians. We summarize and discuss clinical advances and developments in pathophysiology, testing and treatment algorithms of upper/lower airway manifestations of EER.
Recent Findings: Growing evidence supports likely multifactorial causes of laryngeal symptoms, including EER, oropharyngeal pathologies, allergic conditions, and cognitive-affective processes (brain-larynx interaction).
Head Neck
April 2024
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Background: A significant proportion of patients with head and neck squamous cell carcinoma (HNSCC) are malnourished at diagnosis. In this study, we investigated how pretreatment body mass index (BMI) and fat-free mass index (FFMI) correlate with early death, and whether these measurements are useful markers of prognosis for risk stratification of head and neck cancer patients.
Methods: Patients (n = 404) with newly diagnosed, curable HNSCC and WHO performance status 0-2 were prospectively included and met with a study representative before treatment initiation, as well as up to four follow-up visits.
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