The necessity to develop procedures to assess respiratory functions which are independent of collaboration, non-invasive, specific, differentiating and sensitive, is stressed. New measuring methods, like main stream detection for oxygen and carbon dioxide as well as continuous assessment of pulmonary impedance are permissive for this purpose. In addition new characteristic quantities are defined. By using these new tools it is shown that the Tiffeneau-maneuver effects the properties of the bronchial system substantially. Examples of application show clearly that single measurements are not sufficient for characterization of the bronchial system. Instead continuous measurement during a certain closed period are proposed to get a so-called bronchogram. The increased sensitivity possibly makes provocation tests with its risks needless. Experimental results reveal longterm instabilities of the bronchial system, which may be discovered by a longterm-bronchogram in analogy to a longterm electrocardiogram. A new detector for the skin is presented; it allows the determination of an intracutaneous oxygen partial pressure as well as the oxygen conductivity of the skin. All results offer possibilities of functional analysis as mentioned above.
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Reumatologia
December 2024
Department of Rheumatology and Immunology, Jagiellonian University Medical College, Krakow, Poland.
Introduction: Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by eosinophilic granulomatous vasculitis. Typical symptoms include late-onset bronchial asthma and blood and tissue eosinophilia. In addition to these characteristic symptoms, EGPA can affect important organs such as the skin, kidneys, heart, sinuses, gastrointestinal tract, and nervous system.
View Article and Find Full Text PDFBiomimetics (Basel)
January 2025
Department of Biology, Texas A&M University, 3258 TAMU, College Station, TX 77843, USA.
In this preliminary study, the long-term effects of calcium chloride crosslinking concentration on viability of 16HBE14o- human bronchial epithelial cells embedded in alginate-extracellular matrix (ECM) or alginate-methylcellulose-ECM hydrogels have been investigated. There is currently a limited understanding regarding the effects of crosslinking solution concentration on lung epithelial cells embedded in hydrogel. Furthermore, the effects of calcium chloride concentration in crosslinking solutions on other cell types have not been reported regarding whether the addition of viscosity and stiffness tuning agents such as methylcellulose will alter the responses of cells to changes in calcium chloride concentration in crosslinking solutions.
View Article and Find Full Text PDFERJ Open Res
January 2025
Copenhagen Academy for Medical Education and Simulation, Rigshospitalet, The Capital Region of Denmark, Copenhagen, Denmark.
Rationale: Flexible bronchoscopy is an operator-dependent procedure. An automatic bronchial identification system based on artificial intelligence (AI) could help bronchoscopists to perform more complete and structured procedures through automatic guidance.
Methods: 101 participants were included from six different continents at the European Respiratory Society annual conference in Milan, 9-13 September 2023.
Front Pharmacol
January 2025
Department of Cardiology, Affiliated Changshu Hospital of Nantong University, Changshu, China.
Objective: This study aims to analyze the adverse drug events (ADEs) associated with tolvaptan in the Food and Drug Administration Adverse Event Reporting System database from the fourth quarter of 2009 to the second quarter of 2024.
Methods: After standardizing the data, various signal detection techniques, including Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network, and Multi-Item Gamma Poisson Shrinker, were employed for analysis.
Results: Among the 7,486 ADE reports where tolvaptan was the primary suspected drug, a total of 196 preferred terms were identified, spanning 24 different system organ classes.
Sci Total Environ
January 2025
Engineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, Shanghai Engineering Research Center of Environmental Biosafety Instruments and Equipment, University of Shanghai for Science and Technology, Shanghai 200093, PR China; Shanghai Institute of Intelligent Science and Technology, Tongji University, Shanghai 200092, PR China.
Metal-Organic Frameworks (MOFs) have shown great promise in environmental protection, owing to their exceptional properties including ultrahigh surface area and porosity, tunable pore size, and easy chemical functionalization. However, emerging evidence from experimental studies indicates that MOFs have side effects on human health due to metal ions doping, resulting in excessive reactive oxygen species (ROS) production, pro-inflammatory responses, and liver fibrosis. In this study, we investigated the impact of MOF-199 on human bronchial epithelial (HBE) cells by using transcriptome sequencing analysis.
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