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Self- versus clinician-collected swabs in anal cancer screening: A clinical trial.
PLoS One
January 2025
Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
Background: Risk of anal cancer is high in certain populations and screening involves collection of anal swabs for HPV DNA and/or cytology testing. However, barriers exist, such as the need for an intimate examination, and stigma around HIV status, sexual orientation, and sexual practices. Self-collected anal swabs (SCA) are a proposed alternative to clinician-collected swabs (CCA) to overcome these barriers.
View Article and Find Full Text PDFIdentification of DNA methylation signatures in follicular-patterned thyroid tumors.
Pathol Res Pract
December 2024
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand; Precision Pathology of Neoplasia Research Group, Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address:
Background And Aims: Follicular-patterned thyroid tumors (FPTTs) are frequently encountered in thyroid pathology, encompassing follicular adenoma (FA), follicular thyroid carcinoma (FTC), noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), and follicular variant of papillary thyroid carcinoma (fvPTC). Recently, a distinct entity termed differentiated high-grade thyroid carcinoma has been described by the 5th edition of the WHO classification of the thyroid tumors, categorized as either high-grade fvPTC, high-grade FTC or high-grade oncocytic carcinoma of the thyroid (OCA). Accurate differentiation among these lesions, particular between the benign (FA), borderline (NIFTP) and malignant neoplasms (FTC and fvPTC), remains a challenge in both histopathological and cytological diagnoses.
View Article and Find Full Text PDFRisk assessment and triage strategy of cervical cancer primary screening on HPV integration status: 5-year follow-up of a prospective cohort study.
J Natl Cancer Cent
December 2024
Department of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Article Synopsis
- The study explored the link between human papillomavirus (HPV) integration and the risk of developing cervical intraepithelial neoplasia (CIN) among women in China.
- It involved 4,086 women, assessing their HPV status and cervical cells over several years, finding that HPV integration was significantly associated with more severe cervical pathology.
- HPV integration testing proved to be more specific and yielded a lower referral rate for further examination compared to standard cytology, suggesting it could be an effective triage method for HPV-positive patients.
Evaluating cervical mucous inflammatory status as novel predictor for spontaneous onset of labour at term: A prospective observational study.
Med J Armed Forces India
December 2024
Director & Professor, Government Institute of Medical Sciences, Greater Noida, UP, India.
Background: The objective of this study was to explore the relationship between cervical inflammatory status at term gestation and spontaneous onset of labour. The was to search for a cost-effective, readily available, point of care test as predictor for spontaneous onset of labour (SPOL) at term.
Methods: This prospective observational cohort study was .
Patient and Tumor Factors on Overall Survival in Spindle Cell Melanoma.
Cureus
November 2024
Oncology, Creighton University School of Medicine, Omaha, USA.
Introduction: Spindle cell melanoma (SCM) is a rare melanoma subtype characterized histologically by atypical, spindled, malignant melanocytes. SCM often presents in older patients and lacks typical cytologic markers, complicating diagnosis and frequently leading to advanced disease upon presentation. While some studies have documented SCM incidence, none have thoroughly examined the demographic, socioeconomic, and treatment factors influencing survival outcomes.
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