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Evaluating key predictors of anatomical complexity in mandibular incisors: insights from CBCT analysis considering premolar anatomy, sex, and age.
Odontology
January 2025
Health Applied Science Post-Graduate Program and Department of Dentistry, Federal University of Juiz de Fora, Campus GV, Governador Valadares, Minas Gerais, Brazil.
Understanding the impact of premolar root anatomy, sex, and age on incisor complexity can aid in developing tailored diagnostic and therapeutic strategies. This study evaluated if the anatomical complexity of mandibular premolars, sex and age can predict the anatomical complexity in mandibular incisors. Using CBCT scans, 3944 mandibular incisors from 493 patients were analyzed.
View Article and Find Full Text PDFOutcome of conservative treatments in patients with TMJ retrodiscal layer rupture or disc perforation.
Clin Oral Investig
January 2025
Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, 101, Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
Objectives: This study was aimed to investigate the efficacy of comprehensive conservative treatments in patients with temporomandibular joint (TMJ) retrodiscal layer rupture and/or disc perforation.
Materials And Methods: This was a retrospective study of thirty-one consecutive patients with findings of TMJ retrodiscal layer rupture and/or disc perforation using magnetic resonance imaging. Comprehensive stomatognathic system assessments were performed.
Genetically predicted brain cortical structure mediates the causality between insulin resistance and cognitive impairment.
Front Endocrinol (Lausanne)
January 2025
Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Background: Insulin resistance is tightly related to cognition; however, the causal association between them remains a matter of debate. Our investigation aims to establish the causal relationship and direction between insulin resistance and cognition, while also quantifying the mediating role of brain cortical structure in this association.
Methods: The publicly available data sources for insulin resistance (fasting insulin, homeostasis model assessment beta-cell function and homeostasis model assessment insulin resistance, proinsulin), brain cortical structure, and cognitive phenotypes (visual memory, reaction time) were obtained from the MAGIC, ENIGMA, and UK Biobank datasets, respectively.
Polyp and tumor microenvironment reprogramming in colorectal cancer: insights from mucosal bacteriome and metabolite crosstalk.
Ann Clin Microbiol Antimicrob
January 2025
Department of Science and Environment, Roskilde University, Roskilde, Denmark.
Background: Highly frequent colorectal cancer (CRC) is predicted to have 3.2 million novel cases by 2040. Tumor microenvironment (TME) bacteriome and metabolites are proposed to be involved in CRC development.
View Article and Find Full Text PDFEpidermal stem cell derived exosomes-induced dedifferentiation of myofibroblasts inhibits scarring via the miR-203a-3p/PIK3CA axis.
J Nanobiotechnology
January 2025
Department of Burns, Wound Repair and Reconstruction, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, 510080, China.
Hypertrophic scar (HS) is a common fibroproliferative disorders with no fully effective treatments. The conversion of fibroblasts to myofibroblasts is known to play a critical role in HS formation, making it essential to identify molecules that promote myofibroblast dedifferentiation and to elucidate their underlying mechanisms. In this study, we used comparative transcriptomics and single-cell sequencing to identify key molecules and pathways that mediate fibrosis and myofibroblast transdifferentiation.
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