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Article Synopsis
  • Antimicrobial resistance (AMR) is a significant global health issue in the 21st century, affecting the burden of disease and mortality linked to bacterial infections across various regions.
  • A comprehensive study was conducted to assess the impact of AMR from 1990 to 2021, analyzing data from 204 countries on deaths and disability-adjusted life years (DALYs) related to 22 pathogens and 84 pathogen-drug combinations.
  • The researchers employed statistical modeling and extensive datasets to estimate AMR's burden, even in areas lacking direct data, considering multiple factors such as sepsis-related deaths and antibiotic resistance rates.
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Introduction: Sickle cell disease (SCD) is a genetic disorder with a high infectious morbidity and mortality and a heterogeneous distribution in France. One of the challenges is to differentiate a bone and joint infection (BJI) from a vaso-occlusive crisis. This challenge is particularly prevalent in French Guiana, an overseas territory with the highest incidence of SCD in France.

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Prospective Spatiotemporal Cluster Detection Using SaTScan: Tutorial for Designing and Fine-Tuning a System to Detect Reportable Communicable Disease Outbreaks.

JMIR Public Health Surveill

June 2024

Bureau of Communicable Disease, New York City Department of Health and Mental Hygiene, Long Island City, NY, United States.

Staff at public health departments have few training materials to learn how to design and fine-tune systems to quickly detect acute, localized, community-acquired outbreaks of infectious diseases. Since 2014, the Bureau of Communicable Disease at the New York City Department of Health and Mental Hygiene has analyzed reportable communicable diseases daily using SaTScan. SaTScan is a free software that analyzes data using scan statistics, which can detect increasing disease activity without a priori specification of temporal period, geographic location, or size.

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This study delves into the previously unexplored territory of extracellular vesicle (EV) cargo and composition, specifically focusing on lipid composition changes in EVs following infection. EVs play crucial roles in intercellular communication, carrying a variety of biomolecules. Investigating how these EV cargo lipids change post-infection with is significant for understanding the molecular mechanisms underlying lipid trafficking during infection.

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Introduction: Zoonoses are a health concern for Aboriginal and Torres Strait Islander peoples in Australia that face elevated risk of disease related to the environment and animals. Internationally, One Health is encouraged to effectively manage zoonoses by taking integrated approaches involving animal, human, and environmental health sectors to improve health outcomes. However, Australia's health systems manage zoonotic diseases in animals and people separately which does not support a One Health approach.

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