[Successful treatment of chronic eosinophilic pneumonia with suplatast tosilate].

Nihon Kyobu Shikkan Gakkai Zasshi

First Department of Internal Medicine, Tokyo Medical College, Japan.

Published: May 1997

AI Article Synopsis

  • A 59-year-old woman presented with symptoms including coughing, sputum production, and difficulty breathing, leading to abnormal findings in chest X-rays.
  • She was diagnosed with chronic eosinophilic pneumonia after finding high eosinophil levels in her blood and lung fluid, along with eosinophil infiltration observed in lung tissue samples.
  • Treatment with suplatast tosilate relieved her symptoms and decreased eosinophil counts, resulting in the resolution of radiographic abnormalities without the use of steroids, with no recurrence reported a year later.

Article Abstract

The patient was a 59-year-old woman who complained of coughing, sputum production, and dyspnea. Abnormal moving shadows were found by chest radiography. There was prolonged eosinophilia in blood. Eosinophilia was also found in bronchoalveolar lavage fluid, and examination of a specimen obtained by transbronchial lung biopsy revealed eosinophil infiltration in alveolar septal walls, which led to a diagnosis of chronic eosinophilic pneumonia. Because of an attack of bronchial asthma and a high level of IL-5 in serum on admission, the patient was given suplatast tosilate. Symptoms were relieved, eosinophil counts in blood and in bronchoalveolar lavage fluid decreased, and the radiographic abnormality disappeared. The patient was not treated with steroids, and there has been no reccurrence to date, one year after discharge.

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