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Disseminated Encephalomyelitis and Myositis in a 3-Month-Old Cane Corso Puppy.
Vet Sci
November 2024
Indiana Animal Disease Diagnostic Laboratory, West Lafayette, IN 47907, USA.
Article Synopsis
- A 3-month-old Cane Corso puppy suffered from severe symptoms, including hindlimb lameness and eventual paralysis, leading to its critical condition at the Purdue Veterinary Hospital.
- Blood tests revealed significant abnormalities, including high levels of creatine kinase, and the puppy tragically went into cardiac arrest shortly after diagnostics.
- Necropsy findings showed widespread muscle degeneration and inflammation, along with protozoal cysts confirmed by elevated antibody levels, highlighting disseminated neosporosis as a rare but critical cause of ascending paresis in young dogs.
Evidence of intrathecally-derived antibodies against Toxoplasma gondii in horses suspected of neurological disease consistent with equine protozoal myeloencephalitis.
Vet Parasitol
June 2023
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, CA 95616, USA. Electronic address:
Among the recognized neurologic diseases in horses, equine protozoal myeloencephalitis (EPM) has been reported around the world and still presents challenges in diagnosis and treatment. Horses can present with clinical neurologic signs consistent with EPM while testing negative for the two main causative agents, Sarcocystis neurona or Neospora hughesi, and may still be clinically responsive to anti-parasitic drug therapy. This context led to our hypothesis that another protozoal parasite, Toxoplasma gondii, which is known to cause toxoplasmosis in other mammalian species, is a potential pathogen to cause neurologic disease in horses.
View Article and Find Full Text PDFIntracranial medulloblastoma as the cause of progressive ataxia in a 6-month-old draft horse cross gelding.
J Vet Intern Med
January 2023
Department of Clinical Studies - New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
We describe the unique clinical presentation of a central nervous system neoplasm in a 6-month-old draft horse cross gelding. Based on the neurologic examination at admission, neurolocalization was most consistent with a mildly asymmetric cervical, multifocal, or diffuse myelopathy. Mild vestibular involvement also was considered, but no cranial nerve deficits were observed.
View Article and Find Full Text PDFNucleoside Triphosphate Hydrolases Assay in Toxoplasm gondii and Neospora caninum for High-Throughput Screening using a Robot Arm.
J Vis Exp
July 2022
Division of Functional Genomics and Therapeutic Innovation, Research Center for Advanced Genomics, Graduate School of Biomedical Sciences, Nagasaki University;
Protozoan parasites infect humans and many warm-blooded animals. Toxoplasma gondii, a major protozoan parasite, is commonly found in HIV-positive patients, organ transplant recipients and pregnant women, resulting in the severe health condition, Toxoplasmosis. Another major protozoan, Neospora caninum, which bears many similarities to Toxoplasma gondii, causes serious diseases in animals, as does Encephalomyelitis and Myositis-Polyradiculitis in dogs and cows, resulting in stillborn calves.
View Article and Find Full Text PDFEquine Protozoal Myeloencephalitis.
Vet Clin North Am Equine Pract
August 2022
Department of Veterinary Science, M.H. Gluck Equine Research Center, University of Kentucky, 108 Gluck Equine Research Center, Lexington, KY 40546-0099, USA. Electronic address:
Advances in the understanding of equine protozoal myeloencephalitis (EPM) are reviewed. It is now apparent that EPM can be caused by either of 2 related protozoan parasites, Sarcocystis neurona and Neospora hughesi, although S neurona is the most common etiologic pathogen. Horses are commonly infected, but clinical disease occurs only infrequently; the factors influencing disease occurrence are not well understood.
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