Objectives: To determine whether the levels of nitric oxide found in hospital compressed air have a clinically relevant effect on oxygenation in intubated patients with normal lungs.
Design: Prospective study.
Setting: Cardiothoracic and surgical intensive care unit in a university hospital.
Patients: Twelve postoperative patients receiving mechanical ventilation.
Interventions: Pure nitrogen and oxygen were substituted for hospital compressed air as a source of blending for correct FIO2.
Measurements And Main Results: Hemodynamics and PaO2 were measured in nitrogen and oxygen used for blending oxygen during stable FIO2 levels. Inhaled nitric oxide was measured with a nitric oxide-chemiluminescence detector. There was no clinically relevant change in systemic hemodynamics. However, the PaO2 decreased significantly when nitrogen was used for blending. Inhaled nitric oxide levels varied from 2 to 550 parts per billion during use of hospital compressed air; no nitric oxide was detectable during use of nitrogen.
Conclusions: The low concentration of nitric oxide in hospital compressed air improves oxygenation in patients with normal lungs receiving mechanical ventilation.
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