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Evidence of Rapid Infection of Four Sweetpotato Potyviruses in a Commercial Field in California.
Plant Dis
January 2025
Department of Plant Pathology, Foundation Plant Services, Davis, CA 95616, U.S.A.
Sweetpotato ( Lam.) is grown worldwide and is a staple food in many countries. One of the main constraints for sweetpotato production is cultivar decline, caused by the accumulation of viruses and subsequent losses of storage root yield and quality over years of vegetative propagation.
View Article and Find Full Text PDFHospitalization and mortality in children due to COVID-19. A retrospective study from Brazil.
JMIR Pediatr Parent
January 2025
Faculdade de Medicina de Sao Jose do Rio Preto-Brazil, University of Ribeirão Preto, Brazil, Sao Jose do Rio Preto, BR.
Background: Background: COVID-19 is currently one of the most important medical challenges as it affects the entire population, with children being infected as easily as adults.
Objective: The objective of this study was to evaluate the prevalence of mortality in under 19-year-old individuals compared to that of adults.
Methods: This retrospective, observational study analyzed the medical records of all patients diagnosed with COVID-19 by real-time reverse transcription-polymerase chain reaction (RT-PCR) who were hospitalized at Hospital de Base and the Infant and Maternal Hospital of São Jose do Rio Preto, SP, Brazil.
Detection of cervical precancerous lesions and cancer by small-scale RT-qPCR analysis of oppositely deregulated mRNAs pairs in cytological smears.
Front Oncol
January 2025
AO Vector-Best, Novosibirsk, Russia.
Background: Cervical screening, aimed at detecting precancerous lesions and preventing cancer, is based on cytology and HPV testing. Both methods have limitations, the main ones being the variable diagnostic sensitivity of cytology and the moderate specificity of HPV testing. Various molecular biomarkers are proposed in recent years to improve cervical cancer management, including a number of mRNAs encoded by human genes involved in carcinogenesis.
View Article and Find Full Text PDFCMTM4 promotes the motility of colon cancer cells under radiation and is associated with an unfavorable neoadjuvant chemoradiotherapy response and patient survival in rectal cancer.
Oncol Lett
March 2025
Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
Neoadjuvant chemoradiotherapy (nCRT) is the standard treatment for locally advanced rectal cancer (LARC). Pathological complete regression is closely linked to disease outcomes. However, biomarkers predicting nCRT response and patient survival are lacking for LARC.
View Article and Find Full Text PDFPyrimidinergic P2Y1-Like Nucleotide Receptors Are Functional in Rat Conjunctival Goblet Cells.
Invest Ophthalmol Vis Sci
January 2025
Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States.
Purpose: To investigate the presence of uridine-5'-triphosphate (UTP)-activated P2Y1-like nucleotide receptors (P2Y2R, P2Y4R, and P2Y6R) in conjunctival goblet cells (CGCs) and determine if they increase intracellular Ca2+ concentration ([Ca2+]i) and induce mucin secretion.
Methods: Adult, male rat conjunctiva was used for culture of CGCs. To investigate the expression of P2YRs, mRNA was extracted from CGCs and used for reverse transcription PCR (RT-PCR) with commercially obtained primers specific to P2Y2R, P2Y4R, and P2Y6R.
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