AI Article Synopsis
- Hybrid tumors of salivary glands are rare and consist of two distinct types of tumors, and this report describes a unique case of a hybrid carcinoma located in the palate.
- The tumor contained components of adenoid cystic carcinoma and salivary duct carcinoma, and showed varying characteristics in cellular differentiation and activity, identified through various protein markers.
- This case is significant as it is the first to show overexpression of p53 and c-erbB-2 proteins in these hybrid tumor entities, suggesting a link between these proteins and the histological diversity found in salivary gland tumors.
Article Abstract
Hybrid tumours of the salivary glands are very rare entities composed of two different tumours, each of which conforms with an exactly defined category. We describe an unusual hybrid carcinoma of the palate; it was comprised of an adenoid cystic carcinoma and a salivary duct carcinoma with a transitional region. These two different compartments showed different characteristics as regards cellular differentiation, proliferative activity, and expression of oncogene and tumour suppressor oncogene proteins, as revealed by using markers for muscle actin, keratin, vimentin, S-100 protein, GFAP, Ki-67, p53, and c-erbB-2 proteins. This case is the first reported with overexpression of p53 and c-erbB-2 proteins in the tumour entities. Salivary gland tumours consist of heterogeneous histological groups, and each has morphological diversity. This case indicates that some of the oncogene and tumour suppressor oncogene proteins may help to produce the histological heterogeneity of the salivary gland tumour.
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| http://dx.doi.org/10.1007/s004280050060 | DOI Listing |
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