Homosexual persons or human immunodeficiency virus (HIV)-infected patients frequently excrete cysts of nonpathogenic strains of Entamoeba histolytica ("Entamoeba dispar"). However, invasive amoebiasis is rare. We report two patients with AIDS and cytomegalovirus colitis in whom invasive amoebiasis was histologically diagnosed. It is concluded that E. histolytica has to be considered in HIV-infected patients with colitis.
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http://dx.doi.org/10.1128/jcm.35.8.2168-2169.1997 | DOI Listing |
Mol Biol Rep
January 2025
Exercise Applied Physiology Laboratory, Biomedical Department, Research Center in High Altitude Medicine and Physiology, Faculty of Health Sciences, University of Antofagasta, Antofagasta, Chile.
Amoebas are characterized by their unique ability to exist both as free-living organisms and, occasionally, as parasites within host tissues, earning them the designation 'amphizoic amoebae'. While amoebic infections are less prevalent, their health impact can be tremendous, leading to several diseases. In low-income countries, poor sanitation and socioeconomic conditions significantly increase the risk of amoebic infections, particularly E.
View Article and Find Full Text PDFDiagn Microbiol Infect Dis
January 2025
Division of Infectious Diseases, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134, USA; Department of Medicine, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
Entamoeba histolytica infections range from asymptomatic intestinal amebiasis to more severe syndromes like invasive colitis or hepatic abscess. While diagnostic tests available for assessing these infections have evolved, the optimal use of newer diagnostics like enteric multiplex Polymerase Chain Reaction (PCR) panels has not been fully established. Here we describe the case of a 34-year-old male with an amebic liver abscess (ALA) that was diagnosed via multiplex Gastrointestinal (GI) PCR panel on formed stool and subsequently confirmed by testing liver abscess fluid (off-label) on the same multiplex GI PCR panel leading to rapid diagnosis and targeted treatment modification with excellent outcome.
View Article and Find Full Text PDFTrop Doct
January 2025
MD, Senior Resident, Department of Gastroenterology, All India Institute of Medical Sciences, Patna, Bihar, India.
Amoebic liver abscess (ALA), a common tropical infection, is caused by (EH). For decades, the first-line treatment for ALA has been metronidazole which has several drawbacks. The thioredoxin reductase enzyme in EH is essential for its anti-oxidative defence and survival during tissue invasion.
View Article and Find Full Text PDFFront Immunol
December 2024
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, Mexico.
During intestinal and liver invasion by the protozoan parasite , extensive tissue destruction linked to large neutrophil infiltrates is observed. It has been proposed that microbicidal components of neutrophils are responsible for the damage, however, the mechanism by which they are released and act in the extracellular space remains unknown. In previous studies, we have shown that trophozoites induce NET formation, leading to the release of neutrophil granule content into extruded DNA.
View Article and Find Full Text PDFJ Surg Case Rep
December 2024
Bariatric Surgery, Obesity Goodbye Center, Tijuana 22000, Mexico.
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