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Intermittent Fasting Ameliorates β-Amyloid Deposition and Cognitive Impairment Accompanied by Decreased Lipid Droplet Aggregation Within Microglia in an Alzheimer's Disease Model.
Mol Nutr Food Res
January 2025
Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.
Scope: Alzheimer's disease (AD) is the most prevalent form of dementia, lack of effective therapeutic interventions. In this study, we investigate the impact of intermittent fasting (IF), an alternative strategy of calorie restriction, on cognitive functions and AD-like pathology in a transgenic mouse model of AD.
Methods And Results: APP/PS1 mice at 6 months were randomly allocated to two dietary groups: one receiving ad libitum (AL) feeding and the other undergoing IF for 1 month.
Understanding Self-Criticism: A Systematic Review of Qualitative Approaches.
Clin Neuropsychiatry
December 2024
School of Cognitive Psychotherapy, Rome, Italy.
Objective: Self-criticism (SC) is a central transdiagnostic factor in several psychopathological conditions, influencing the development and maintenance of symptomatology. The importance of this construct has stimulated quantitative and qualitative research about it. The main purpose of this systematic review is to highlight which qualitative methods have been used most frequently and which are most suitable for studying SC.
View Article and Find Full Text PDFThreshold effects of sleep duration and cognitive function in older adults with BMI ≥ 25 kg/m.
Front Aging Neurosci
January 2025
Department of General Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Background: It has been demonstrated that older adults' cognitive capacities can be improved with sleep duration. However, the relationship between overweight, obesity, and cognitive decline remains a subject of debate. The impact of sleep duration on cognitive performance in seniors with a body mass index (BMI) ≥ 25 kg/m is largely unknown.
View Article and Find Full Text PDFTherapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer's disease: targeting oxidative stress, inflammation, and the gut-brain axis.
Front Aging Neurosci
January 2025
Department of Geriatric Medicine, Quzhou People's Hospital, Quzhou, China.
Alzheimer's disease (AD) is a complex neurodegenerative disorder, with amyloid-beta (Aβ) aggregation playing a key role in its pathogenesis. Aβ-induced oxidative stress leads to neuronal damage, mitochondrial dysfunction, and apoptosis, making antioxidative strategies promising for AD treatment. This study investigates the effects of hydrogen-rich water (HRW) in a zebrafish AD model.
View Article and Find Full Text PDFHome Healthcare Medication Safety risks among older adults with chronic diseases: a qualitative study.
BMC Nurs
January 2025
Department of Community Health and Geriatric Nursing, Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
Background: Older adults receiving home care often face significant safety risks related to medication management due to their chronic diseases and complex health needs. Despite the increasing reliance on home healthcare services, the specific factors contributing to medication safety risks in this demographic remain inadequately explored.
Objective/aim: This study aims to explore the key factors involved in medication safety risks among older adults with chronic diseases receiving home healthcare in Iran.
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