Objective: To evaluate the efficacy of itraconazole-dimethyl sulfoxide ointment for treatment of keratomycosis in horses in the northeastern United States.
Design: Prospective clinical trial.
Animals: 9 horses (10 affected eyes).
Procedure: All horses treated for keratomycosis at Cornell University between July 1994 and July 1996 were included in the study. The diagnosis of keratomycosis was confirmed by cytologic examination, and all horses were treated with 0.25 ml of a 1% itraconazole-30% dimethyl sulfoxide petrolatum-based ointment, applied to the affected eye every 4 hours.
Results: Topical application of itraconazole-dimethyl sulfoxide ointment (q 4 h) resolved keratomycosis in 8 of 10 eyes; mean duration of treatment was 34.6 days (range, 16 to 53 days).
Clinical Implications: Results of this study indicate topical administration of itraconazole-dimethyl sulfoxide ointment may provide an additional treatment option for horses with keratomycosis.
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Evaluation of itraconazole-dimethyl sulfoxide ointment for treatment of keratomycosis in nine horses.
J Am Vet Med Assoc
July 1997
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Objective: To evaluate the efficacy of itraconazole-dimethyl sulfoxide ointment for treatment of keratomycosis in horses in the northeastern United States.
Design: Prospective clinical trial.
Animals: 9 horses (10 affected eyes).
Corneal concentrations and preliminary toxicological evaluation of an itraconazole/dimethyl sulphoxide ophthalmic ointment.
J Vet Pharmacol Ther
April 1997
Department of Clinical Science, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
The objectives of this study were to determine the concentration of itraconazole achieved in corneal tissue and aqueous humour after topical application of a 1% itraconazole ointment: to determine the effect of including dimethyl sulphoxide (DMSO) in the ointment on achievable ocular tissue itraconazole concentrations; and to assess if any gross or histopathologic ocular toxicity results from the topical application of 1% itraconazole with or without the addition of DMSO. The experimental trial consisted of 6 horses considered to have normal eyes. Each horse had one eye treated with 0.
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