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Reprint of: Fluorescence and the Structure of Proteins. I. Effects of Substituents on the Fluorescence of Indole and Phenol Compounds.
Arch Biochem Biophys
September 2022
From the Department of Biochemistry, University of Colorado School of Medicine, Denver, Colorado.
The quantum efficiency of fluorescence was measured for simple derivatives of indole and phenol and for tryptophyl and tyrosyl residues in peptides and proteins. Fluorescence of these compounds decreased as the electronegativity of substituents increased. In proteins, one strongly electronegative structure is the peptide bond.
View Article and Find Full Text PDFVibrational circular dichroism of d-amino acid-containing peptide NdWFamide in the crystal form.
Chirality
October 2021
Graduate School of Engineering Science, Yokohama National University, Yokohama, Japan.
Microcrystals of l-Asn-d-Trp-l-Phe-NH (NdWFamide), a tripeptide derived from Aplysia kurodai that exhibits invertebrate cardiac activity, were evaluated by vibrational circular dichroism (VCD). The chirality of the tryptophan residue at the second position in NdWFamide was associated with the conformation and biological characteristics. The VCD spectrum of NdWFamide was a mirror image of its enantiomer; however, it was significantly different from that of its diastereomer, NWFamide, which is its precursor.
View Article and Find Full Text PDFElucidating Relayed Proton Transfer through a His-Trp-His Triad of a Transmembrane Proton Channel by Solid-State NMR.
J Mol Biol
June 2019
Department of Chemistry, Massachusetts Institute of Technology, 170 Albany Street, Cambridge, MA 02139, USA. Electronic address:
Proton transfer through membrane-bound ion channels is mediated by both water and polar residues of proteins, but the detailed molecular mechanism is challenging to determine. The tetrameric influenza A and B virus M2 proteins form canonical proton channels that use an HxxxW motif for proton selectivity and gating. The BM2 channel also contains a second histidine (His), H27, equidistant from the gating tryptophan, which leads to a symmetric HxxxWxxxH motif.
View Article and Find Full Text PDFAltered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8 T Cell-Effector Responses.
Cancer Immunol Res
December 2018
Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.
T-cell priming occurs when a naïve T cell recognizes cognate peptide-MHC complexes on an activated antigen-presenting cell. The circumstances of this initial priming have ramifications on the fate of the newly primed T cell. Newly primed CD8 T cells can embark onto different trajectories, with some becoming short-lived effector cells and others adopting a tissue resident or memory cell fate.
View Article and Find Full Text PDFAnti-inflammatory Effects of PMX205 in Mouse Macrophage Periodontitis Model.
Iran J Immunol
June 2018
Department of Periodontics, School of Stomatology, Jilin University, Changchun, Jilin, China.
Background: C5a receptor antagonist PMX205 is a synthetic hexapeptide capable of blocking C5a-C5a receptor (C5aR) axis by simulating C5a active C-terminal amino acid residues. This hexapeptide presents good anti-inflammatory effects in a series of inflammation models. The anti-inflammatory effect of PMX205 on periodontitis is yet to be fully fathomed.
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