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| http://dx.doi.org/10.1136/bmj.314.7097.1828a | DOI Listing |
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Ocular Manifestations in Selected Dermatological Disorders: A Narrative Review.
Ocul Immunol Inflamm
March 2025
Faculty of Medicine, Poznan University of Medical Sciences, Poznan, Poland.
Skin disorders are often associated with ocular symptoms. In this review, we aim to identify the most common ocular manifestations observed in selected dermatological diseases, specifically psoriasis, atopic dermatitis, rosacea, and pemphigus. We highlight key ophthalmological conditions linked to these diseases to raise awareness among ophthalmologists who may encounter patients with these dermatological conditions in their clinical practice.
View Article and Find Full Text PDF[Early conversion to belatacept post-transplantation: state of the art and expert opinion].
Nephrol Ther
March 2025
Néphrologie, hémodialyse, aphérèse et transplantation, CHU Grenoble Alpes, La Tronche, France
Article Synopsis
- The standard immunosuppressive regimen after organ transplantation typically includes drugs like tacrolimus, mycophenolic acid, and corticosteroids, which can cause side effects like kidney damage.
- Belatacept offers a promising alternative by blocking a key costimulation pathway, showing improved kidney function and reduced donor-specific antibodies in early studies, despite a higher risk of acute rejections.
- Research highlights the benefits of converting to belatacept within the first six months after kidney transplantation, while also emphasizing the need for careful monitoring of rejection and infection risks.
A perfused iPSC-derived proximal tubule model for predicting drug-induced kidney injury.
Toxicol In Vitro
May 2025
TissUse GmbH, Berlin, Germany. Electronic address:
The kidney is frequently exposed to high levels of drugs and their metabolites, which can injure the kidney and the proximal tubule (PT) in particular. In order to detect nephrotoxicity early during drug development, relevant in vitro models are essential. Here, we introduce a robust and versatile cell culture insert-based iPSC-derived PT model, which can be maintained in a microphysiological system for at least ten days.
View Article and Find Full Text PDFMechanisms of Mitochondria-Mediated Apoptosis During Infection.
Animals (Basel)
February 2025
College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong 030801, China.
Coccidiosis in chickens is a parasitic disease caused by species, resulting in significant economic losses to the poultry industry. Among these species, is considered the most virulent pathogen, with its infection strongly associated with the apoptotic response of host cells. modulates host cell apoptosis in a stage-specific manner, suppressing apoptosis in the early phase to promote its intracellular development and triggering apoptosis in later stages to facilitate parasite egress and disease progression.
View Article and Find Full Text PDFCharacteristics and Outcomes of Generalized Pustular Psoriasis Patients Managed Through Inpatient Asynchronous Teledermatology: A Retrospective Study.
Telemed Rep
January 2025
Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA.
Background: Inpatient teledermatology (ITD) is a growing telemedicine modality aimed at addressing the shortage of dermatologists in hospitals, particularly for the management of complex skin disorders. Generalized pustular psoriasis (GPP) is a rare and potentially life-threatening condition characterized by widespread sterile pustules and systemic inflammation. Despite advances in targeted therapies, treatment is often limited to traditional agents such as cyclosporine and infliximab, due to restrictions in formulary access and insurance coverage.
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