Purpose: We report a patient with progressive idiopathic, nonulcerative, noninflammatory, avascular, bilateral, paracentral and peripheral corneal thinning monitored for 13 years.
Methods: Because of progressive corneal thinning, the patient underwent several surgical procedures, including an arcuate lamellar keratectomy with suturing, bilateral 15-mm diameter onlay lamellar corneoscleral epikeratoplasties, and removal of interface epithelial tissue. Over time, the keratolysis also thinned the donor stroma, requiring a lamellar tectonic graft. A biopsy was performed of the patient's cornea and conjunctiva, and the tissue was analyzed for proteolytic enzymes.
Results: Increased quantities of matrix metalloproteinases (57 and 63 kDa) were extracted from the patient's normal-appearing and abnormal corneal samples but not from adjacent conjuctiva and sclera or normal controls. This is the first reported case with these clinical and laboratory findings.
Conclusion: A previously undescribed progressive idiopathic paracentral keratolysis is associated with increased quantities of matrix metalloproteinases. Clinical management requires tectonic corneal surgery.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Miltefosine-related paracentral ulcerative keratolysis in a patient with active cutaneous leishmaniasis from Nepal.
Trop Doct
October 2020
Resident, Department of Ophthalmology, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.
Peripheral corneal ulceration associated with rheumatoid arthritis.
Am J Case Rep
August 2013
Laboratory of Experimental Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Patient: Female, 60 FINAL DIAGNOSIS: Corneal ulceration Symptoms: Blurred vision Medication: Abatacept Clinical Procedure: - Specialty: Ophthalmology.
Objective: Management of emergency care.
Background: To report a case of a patient with rheumatoid arthritis (RA) and associated peripheral corneal ulceration.
Progressive keratolysis with pseudopterygium associated with erythema elevatum diutinum.
Ophthalmology
May 2011
Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Objective: To report a patient with a rare case of progressive keratolysis with pseudopterygium associated with erythema elevatum diutinum (EED).
Design: Interventional case report and literature review.
Participant: One patient with ocular presentation of EED was identified.
Progressive nonulcerative paracentral keratolysis associated with elevated corneal metalloproteinases.
Cornea
July 1997
Department of Ophthalmology, Emory University, Atlanta, Georgia, USA.
Purpose: We report a patient with progressive idiopathic, nonulcerative, noninflammatory, avascular, bilateral, paracentral and peripheral corneal thinning monitored for 13 years.
Methods: Because of progressive corneal thinning, the patient underwent several surgical procedures, including an arcuate lamellar keratectomy with suturing, bilateral 15-mm diameter onlay lamellar corneoscleral epikeratoplasties, and removal of interface epithelial tissue. Over time, the keratolysis also thinned the donor stroma, requiring a lamellar tectonic graft.
Paracentral rheumatoid corneal ulceration. Clinical features and cyclosporine therapy.
Ophthalmology
January 1992
Department of Ophthalmology, University of Miami School of Medicine, FL.
Six patients with rheumatoid arthritis (eight eyes) presented with small paracentral perforating corneal ulcers in otherwise quiet eyes. Initial management in five patients (seven eyes) consisted of systemic immunosuppression and therapeutic tissue adhesive with a bandage contact lens or tectonic keratoplasty. Ulceration recurred in all of these eyes, and recurrent ulcers treated with repeat tectonic keratoplasty or therapeutic tissue adhesive and a bandage contact lens all developed recurrent ulceration.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!