We report on a family with leukonychia totalis, koilonychia and multiple sebaceous cysts segregating as an autosomal dominant disorder. This condition has only previously been described in two kindreds, and this report documents the natural course of the disorder and provides further evidence for pancreatitis being an associated syndromic feature.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00019605-199707000-00005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Idiopathic acquired true leukonychia: a unique entity.
Acta Dermatovenerol Alp Pannonica Adriat
September 2024
Department of Dermatology, School of Medicine, University of Jordan, Amman, Jordan.
Idiopathic acquired true leukonychia is a rare benign acquired disorder that typically affects adults. Diagnosis is made clinically, with investigations required to exclude any underlying cause. The cause of this condition is largely unknown, yet it understandably causes significant anxiety to patients due to concerns about underlying systemic disease.
View Article and Find Full Text PDFLeukonychia Totalis: An Underreported Sign of Chronic Arsenicosis.
Skin Appendage Disord
August 2024
Department of Forensic Medicine and Toxicology, K. D. Medical College, Mathura, India.
Article Synopsis
- * A case study involved a 27-year-old male who experienced nail discoloration and tingling after using herbal bodybuilding supplements, revealing elevated arsenic levels and leading to a diagnosis of chronic arsenicosis with severe nail changes and early nerve damage.
- * Chronic arsenicosis can cause various skin and nail conditions, such as pigment changes and hair loss; notable findings include total leukonychia, which hasn't been reported before as a result of arsenic exposure.
FLOTCH Syndrome: A Case of Leukonychia Totalis and Multiple Pilar Cysts.
Cutis
October 2023
Oakland University William Beaumont School of Medicine, Rochester, Michigan. Dr. Ryan Brothers and Dr. Ross Brothers also are from Northwest Dermatology Group, Bingham Farms & Washington Township, Michigan, and the Michigan State University College of Human Medicine, East Lansing.
FLOTCH (leukonychia totalis-trichilemmal cysts-ciliary dystrophy syndrome) syndrome is a rare genetic cutaneous disorder primarily characterized by multiple recurrent trichilemmal pilar cysts and leukonychia. It may be associated with ciliary dystrophy, koilonychia, and/or less frequently renal calculi and pancreatitis inherited in an autosomal-dominant fashion. We report the case of a 25-year-old Black woman who presented with white-colored fingernails and enlarging cysts in multiple locations including the scalp, rib cage, and forearm and was diagnosed with suspected FLOTCH syndrome.
View Article and Find Full Text PDFIdentification of a Novel Variant in a Danish Family with Hereditary Leukonychia.
Skinmed
March 2023
Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
A 1-year-old girl presented with porcelain white fingernails, accidentally discovered when she was referred for an infantile hemangioma consultation. The family reported that the nails had been milky white since birth and her father had similar white finger and toenails. The father remembered that additional family members on his side of the family presented with white nails; however, he could not provide exact information about the number of other relatives affected by this nail abnormality.
View Article and Find Full Text PDFClinical and capillaroscopic findings in patients with liver disease and proximal apparent leukonychia (Terry nails and its variants).
Medicine (Baltimore)
June 2021
Department of Internal Medicine and Hepatology.
Terry nails and Lindsay nails are similar forms of proximal apparent leukonychia (PAL). A change in nail bed vascularity is thought to be responsible for PAL. The study was aimed at investigating the frequency of PAL in patients attending a liver disease clinic, the factors associated with its presence, its value for detecting cirrhosis, its prognostic value for mortality, and associated capillaroscopic findings.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!